Introduction: Acne scars are common, and their treatment is challenging. Several techniques have been used to remove, reposition, and flatten acne scars to improve the appearance of the skin’s surface. More recently, fractional CO₂ laser has been used to correct such scars due its good results and shorter recovery time.
Objective: To evaluate and compare fractional CO₂ laser vs. dermabrasion-based treatment of acne scars.
Methods: Nine patients were assessed – six received fractional CO₂ laser and three were treated with dermabrasion. Subjective and objective parameters were evaluated for both treatment modalities.
Results: Both patient groups showed objective and subjective improvement.
Conclusions: This study has demonstrated that fractional CO₂ laser and dermabrasion-based treatments have similar efficacy in moderate to severe acne scars.

Keywords: CICATRIX; ACNE VULGARIS; LASER THERAPY.

Introduction: Scars caused by burns have the potential to cause clinical, social, and functional disruptions. Dermatologists should be able to intervene in this process by combining technological advances with traditional techniques. Objective: To evaluate the effect of Intense Pulsed Light applications on scars after burns, based on clinical parameters described in the international Vancouver Scar Scale. Methods: A prospective study was carried out with six patients who underwent five monthly Intense Pulsed Light sessions over the entire area of a wound. The analysis of the results was conducted by three evaluation groups: 3 physician researchers, the patients included in the study, and 3 physician observers. The evaluation was implemented using the Vancouver Scale, a questionnaire based on this scale, and additionally a general rating used by all evaluators based on a numerical scale. The data obtained by examining the differences before and after the treatment, was analyzed through the Wilcoxon signed-rank test. Results: A statistically significant decrease was observed in the analyses of all clinical parameters of the scars, when evaluated before and after the completion of the treatment. Conclusions: The present pilot study demonstrates the advantages of Intense Pulsed Light as an approach to this specific type of scar, with an aim of stimulating further studies in order to improve this low-cost technology, as compared to lasers.

Keywords: LASERS; INTENSE PULSED LIGHT THERAPY; CICATRIX; BURNS.

A range of treatment options is available to restore and increase dermal collagen. The purpose of the present review, based on articles selected on PubMed database, is to study the histological effect of four methods for skin rejuvenation: Intense Pulsed Light, non-ablative fractional laser, ablative fractional laser and percutaneous collagen induction. The therapeutic implications of each type of treatment will depend on the induced collagen type and its ability to elicit a regenerative healing response versus a fibrotic scarring response. Intense Pulsed Light and the percutaneous collagen induction produced regenerative healing response with increased collagen type I.

Keywords: INTENSE PULSED LIGHT; LASER THERAPY; COLLAGEN; REJUVENATION; SKIN AGING

Use of botulinum toxin type A in first intention healing wounds has been widely adopted in order to inhibit the formation of hypertrophic scars. In this report we demonstrate the use of the toxin in a surgical wound left to heal by secondary intention, after the removal of a squamous cell carcinoma in situ by Mohs micrographic surgery in supralabial region, with good cosmetic result. Botulinum toxin acts by inhibiting the proliferation of fibroblasts, by differentiating fibroblasts and by producing type I collagen, which are the main factors responsible for the good quality of the healing process.

Keywords: BOTULINUM TOXINS, TYPE A; CICATRIX; WOUND HEALING; CARCINOMA, SQUAMOUS CELL

Keloids have functional, aesthetic and psychological impacts that can influence the patients' quality of life. Moreover, given the high rate of recurrence – particularly in large lesions located in the anterior thoracic region – they are more difficult to treat. This paper reports a successful treatment for keloids in this area using a new technique that combines intense pulsed light, botulinum toxin type A and the conventional treatment with injection of corticosteroids.

Keywords: KELOID; INTENSE PULSED LIGHT THERAPY; BOTULINUM TOXINS, TYPE A; ADRENAL CORTEX HORMONE

INTRODUCTION: Acne scars treatment is challenging since, in the most of the cases, there are different types of scars in the same patient.
OBJECTIVE: Associate three distinct acne scar treatment techniques in the same session in order to optimize results.
METHODS: Retrospective observational study evaluating 25 patients with acne scars treated with the following sequence of associated techniques: high frequency electrosurgery, CO₂ laser and Nd:YAP laser.
RESULTS: High patient satisfaction index and evident improvement in photographs in most of cases.
CONCLUSIONS: The combination of techniques in one session was safe and effective in the treatment of acne scars, a condition of great psychological impact to affected individuals.

Keywords: Acne vulgaris; Cicatrix; Laser therapy

Botulinum toxin has transient flaccid neuromuscular paralysis as its mechanism of action. Recent studies are identifying new ways to use botulinum toxin for a variety of purposes, both in the aesthetic and in the therapeutic field. This work aimed to conduct a literature review on these applications. In the aesthetic field, botulinum toxin has shown benefit in the treatment of hypertrophic scars, rejuvenation of the scrotal region, definition of the gastrocnemius muscle, and microdoses use. In the treatment of pathologies, the review has shown that botulinum toxin may be useful for the treatment of post-herpetic neuralgia and other pain syndromes, craniofacial hyperhidrosis, rosacea, and Hailey-Hailey disease.

Keywords: Botulinum toxins; Botulinum toxins, Type A; Esthetics; Pruritus; Rejuvenation; Cicatrix; Cicatrix, Hypertrophic

Necrobiosis Lipoidica (NL) is a granulomatous dermatosis, mainly affecting people with diabetes due to collagen degeneration. Although there are different treatments, all have little response. Among the options, the Intense Pulsed Light (IPL) and the Laser Erbium-YAG enhance the production and remodeling of the collagen treating the atrophy, besides reducing the erythema by the coagulation of blood vessels. We report a case of a 24-year-old woman with type I Diabetes Mellitus who underwent NL treatment on her left forearm in seven sessions with the association of IPL and 2940 nm Erbium-YAG laser. We observed improvement in central atrophy and erythema.

Keywords: Necrobiosis lipoidica; Diabetes mellitus; Lasers; Laser therapy; Intense pulsed light therapy; Collagen

O queratoacantoma (QA), apesar de frequente na prática diária, é um tumor que gera questionamentos. O aspecto mais intrigante associa-se à sua posição no limite entre malignidade e benignidade. A abordagem do tumor, bem como sua classificação, é controversa. Na definição da conduta, é importante levar em conta o potencial de transformação para carcinoma espinocelular. Desse modo, a excisão cirúrgica é a terapia de escolha, sempre que possível. Algumas situações merecem atenção adicional, como a imunossupressão associada. Neste artigo, relatamos um caso de QA gigante em um paciente com síndrome da imunodeficiência adquirida tratado com cirurgia micrográfica de Mohs.

Keywords: Ceratoacantoma; Retalhos Cirúrgicos; Neoplasias Nasais; Neoplasias Cutâneas; Cirurgia de Mohs; Síndrome de Imunodeficiência Adquirida; HIV; Imunossupressão

Sarcomas são neoplasias mesenquimais malignas, raras, que acometem, principalmente, crianças e adolescentes. O rabdomiossarcoma, subtipo oriundo da musculatura esquelética, é condição incomum em adultos, acometendo sítios de localização não habitual, crescimento rápido e de difícil tratamento. Apresenta-se caso de adulto jovem com nodulação em lóbulo auricular esquerdo, cuja análise histopatológica e imuno-histoquímica confirmou tratar-se de rabdomiossarcoma alveolar, o qual foi conduzido em conjunto com a Oncologia.

Keywords: Rabdomiossarcoma Alveolar; Miogenina; Desmina; Excisão de Linfonodo

Facial surgeries are often challenging for surgeons due to their complex anatomy, aesthetic and functional importance. Interventions in the cosmetic subunit that comprises the eyebrows can be particularly difficult. This case report aims to demonstrate the use of island flap in this region. We performed the excision of melanocytic nevus, with a good outcome and absence of postoperative complications. This technique is commonly used for facial reconstruction; however, the literature describes only a few cases using this method for eyebrow reconstruction.

Keywords: Scleroderma, Systemic; Microstomia; Lasers; Laser Therapy; Intense Pulsed Light Therapy; Combined Modality Therapy

Congenital vascular lesions can be subdivided into tumors and malformations. Hemangiomas are benign vascular tumors resulting from the abnormal proliferation of endothelial cells, whereas port-wine stains are vascular malformations of a possible autosomal dominant inheritance. To date, there are no studies associating the use of intense pulsed light and CO2 laser as a therapeutic form for these pathologies. We present a series of 10 cases of vascular injuries treated with the combination of these forms of irradiation. This combined therapy can be effective in reducing the thickness of the lesions or in attenuating the color.

Keywords: Hemangioma; Lasers, gas; Laser therapy; Intense pulsed light therapy; Vascular malformations

Intense Pulsed Light (IPL) is an effective technology to treat vascular lesions, pigmented lesions, and photorejuvenation, among other indications. In the case of telangiectasia, its mechanism of action is based on photothermolysis of the vessels, inducing intravascular coagulation. We report three cases where IPL was used to treat telangiectasia in a surgical scar, showing good aesthetic results after three sessions.

Keywords: Cicatrix; Telangiectasis; Intense Pulsed Light Therapy; Erythema

Atrophic acne scars result from an abnormal wound-healing response that can be treated with microneedling (MN). Insulin may play a role in wound healing. The effectiveness and safety of combining MN with topical insulin as an alternative therapy for atrophic acne scar revision have not yet been widely reported. We report the case of a 33-year-old woman with an atrophic acne scar on the middle third of her face. The patient was treated with MN and topical insulin for four sessions at two-week intervals. MN plus insulin can be considered an alternative for acne scar revision.

Keywords: Acne Vulgar; Insulina; Cicatriz; Hiperpigmentação

BACKGROUND: Wound healing is a complex process, and various factors can disrupt this process, leading to non-healing wounds or scarring. Conventional treatments for scar management often have low efficacy and high recurrence rates. The combination of intense pulsed light (IPL) and fractional laser therapy (FLT) has emerged as a minimally invasive alternative with promising results. The goal of this study was to evaluate the safety and efficacy of combined IPL + FLT therapy and to manage pathological scars.
METHODS: This study followed PRISMA guidelines. Systematic searches were performed in PubMed, ProQuest, Scopus, and the Cochrane Library up to December 2025. Studies involving patients with pathological scars treated using combination IPL and FLT were included.
RESULTS: Five studies met the eligibility criteria, comprising 3 randomized controlled trials, 1 retrospective cohort study, and 1 case series, totaling 288 patients. Across all studies, combination therapy produced significant reductions in POSAS, MSS, and VSS scores in hypertrophic and postoperative scars. One study reported significantly higher patient satisfaction rates (p<0.05). Adverse effects were minimal, primarily mild transient erythema.
CONCLUSION: Combined FLT and IPL safely enhance scar appearance, with low adverse effect rates, offering an effective and minimally invasive therapeutic option.

Keywords: Keloid; Cicatrix, Hypertrophic; Laser Therapy; Intense Pulsed Light Therapy