Introduction: The subungual glomus tumor is characterized by painful nodules triggered by thermal and tactile change. A complete lesion excision is the treatment of choice but relapses are frequent. Objective: To compare the rates of recurrence of conventional surgeries described in the literature with the ones we found after the Mohs micrographic surgery (MMS). Material and ethods: We included 10 patients diagnosed with subungual glomus tumor of which 9 were female and 1 male and who also underwent withdrawal of these lesions by the technique of Mohs micrographic surgery. Results: Of the 10 patients, eight were considered cured after following 14 to 93 months (around 47.8 months). There were two recurrences which occurred after 47 and 51 months, respectively. One case was reoperated by MMS without evidence of disease after 24 months. Conclusion: The results obtained with the use of MMS in subungual glomus tumors were similar to those reported in the literature with conventional techniques, usually with more limited follow-up.

Keywords: MICROGRAPHIC SURGERY, MOHS MICROGRAPHIC SURGERY, GLOMUS TUMOR

Introduction: The granular cell tumor was first described by Abrikossoff in 1926. It is a benign, uncommon neoplasia, most frequently found on the tongue. It occurs in the vulva in 5 to 6% of cases. Its histogenesis is not known for sure, but is probably linked to Schawann cells. It is treated surgically, with a good prognosis. The tumors may recur, and some may become malignant according to the literature. The authors describe a case of a vulvar nodule with a histopathologic diagnosis of granular cell tumor, which was successfully treated with surgery.

Keywords: VULVA, VULVAR DISEASES, VULVAR NEOPLASMS, GRANULOSA CELL TUMOR

Introduction: Glomus tumors are rare benign lesions that are most often found on the tips of the fingers; they account for 1.0-4.5% of neoplasias on the hand. Subungual glomus tumors occur more frequently in women in their 30s and 50s.
Objective: This study evaluated glomus tumor patients'''''''' epidemiological profiles, their satisfaction with the treatment and the rate of recurrence due to incomplete removal.
Method: The records of patients that were treated for glomus tumors at a dermatology clinic between 1992 and 2011 were evaluated regarding gender, age, profession, affected area of the body, satisfaction with the treatment and possible recurrence.
Results: The patients (n = 8, average 63 years) were older than those usually described in the literature. The most frequently described profession was that of housewife. All patients were satisfied with the aesthetic results of the treatment. There was a total improvement of the pain in threepatients, while patients with a partial improvement in pain experienced a recurrence. The recurrence rate due to incomplete removal was 50%.
Conclusion: The surgery''''''''s effectiveness can be measured by the improvement of the pain; persistence of pain can indicate recurrence.

Keywords: THERAPEUTICS, GLOMUS TUMOR, NAILS

Palisaded encapsulated neuromas are solitary neural skin tumors characterized by the presence of compact and parallel bundles of Schwann cell fascicles. The present article reports a case of this type of tumor, which was confirmed by anatomic pathological examination of a 55-year-old female patient who reported hypochromic macula growth, which had evolved into a smooth domed superficial papule with telangiectasias, simulating a basal cell carcinoma. Having knowledge of this entity is crucial in order to carry out differential diagnoses-comparing it to other lesions-especially basal cell carcinomas, skin appendage tumors, nevi, and epidermal cysts.

Keywords: NEUROMA, SKIN NEOPLASMS, SCHWANN CELLS

Case report of a male patient bearing a rare granular cell tumor in the left arm, confirmed by histology and immunohistochemistry (positive S100 and CD68 proteins).

Keywords: ARM; GRANULAR CELL TUMOR; SKIN NEOPLASMS

Eccrine spiradenoma is a rare benign adnexal epithelial neoplasm characterized by a bluish-pink, slow-growing solitary nodule, coursing with paroxysmal pain, mainly in young adults. It is most commonly located in the trunk and extremities. Bleeding and/or ulceration are common in the giant vascular variant, which is characterized by a size greater than 2 cm in diameter and a high degree of vascularization seen on histology. Its clinical characteristics are unspecific and require biopsy with histological analysis for diagnosis. Its histology presents one or more basophilic intradermal lobules enveloped in a fibrous capsule without connection to the epidermis. It presents two types of cells: small cells with dark nuclei in the periphery and large cells with light nuclei in the center. An accurate diagnosis is important due to the fact that it can develop into a potentially fatal malignancy - which is a rare phenomenon and occurs most often in the multiple variant. A rare case of eccrine spiradenoma in the abdomen with bleeding associated is described in the present paper, as well as a discussion on possible treatments.

Keywords: ECCRINE SPIROADENOMA, BENIGN EPITHELIAL NEOPLASIA, SEBACEOUS GLANDS

The granular cell tumor, also known as Abrikossoff tumor, is a rare neoplasm with controversial etiology that usually arises as a solitary benign lesion. The authors describe a case of multicentric granular cell tumor in a 13-year old patient treated with surgical excision.

Keywords: GRANULAR CELL TUMOR; NEOPLASMS, SOFT TISSUE NEOPLASMS; S100 PROTEINS

Introduction: Glomus tumor is a benign and rare neoplasm that appears as solitary and painful nodule, mainly subungual. It presents characteristic clinical manifestations such as paroxysmal pain and sensitivity to local pressure and to cold.
Objective: To conduct a clinical epidemiological survey of glomus tumors diagnosed in a reference unit in 16 years.
Methods: Retrospective study assessing clinical and epidemiological data of 15 patients with glomus tumor confirmed by histopathological report from 2000 to 2016. Data on age, gender, tumor location, associated symptoms, duration of symptoms until diagnosis, clinical presentation, histological type and recurrence after surgery were analysed.
Results: Fifteen cases were diagnosed, 11 in women (73.3%) and four in men (26.7%). Mean age was 63 years. The most frequent location was the subungual region. Mean duration of symptoms until diagnosis was 8 years.
Conclusions: In this study, the number of cases of glomus tumor fluctuated throughout these 16 years, with a mean of 0.9 cases/year. A higher prevalence in women over 60 years, subungual region location and solid glomus histologic subtype was observed.

Keywords: GLOMUS TUMOR; NAIL DISEASES; NEOPLASMS

O queratoacantoma (QA), apesar de frequente na prática diária, é um tumor que gera questionamentos. O aspecto mais intrigante associa-se à sua posição no limite entre malignidade e benignidade. A abordagem do tumor, bem como sua classificação, é controversa. Na definição da conduta, é importante levar em conta o potencial de transformação para carcinoma espinocelular. Desse modo, a excisão cirúrgica é a terapia de escolha, sempre que possível. Algumas situações merecem atenção adicional, como a imunossupressão associada. Neste artigo, relatamos um caso de QA gigante em um paciente com síndrome da imunodeficiência adquirida tratado com cirurgia micrográfica de Mohs.

Keywords: Ceratoacantoma; Retalhos Cirúrgicos; Neoplasias Nasais; Neoplasias Cutâneas; Cirurgia de Mohs; Síndrome de Imunodeficiência Adquirida; HIV; Imunossupressão

Sarcomas são neoplasias mesenquimais malignas, raras, que acometem, principalmente, crianças e adolescentes. O rabdomiossarcoma, subtipo oriundo da musculatura esquelética, é condição incomum em adultos, acometendo sítios de localização não habitual, crescimento rápido e de difícil tratamento. Apresenta-se caso de adulto jovem com nodulação em lóbulo auricular esquerdo, cuja análise histopatológica e imuno-histoquímica confirmou tratar-se de rabdomiossarcoma alveolar, o qual foi conduzido em conjunto com a Oncologia.

Keywords: Rabdomiossarcoma Alveolar; Miogenina; Desmina; Excisão de Linfonodo

Neurofibromatosis type I (NF1) is an autosomal dominant disease, with an incidence of 1/2,500-3,000 births and a prevalence of approximately 1/4,000-5,000 individuals. Genetic mutations in the NF1 gene cause it, affecting neural and skin tissues. Glomus tumor is a benign neoplasm originating from the glomus, a neuromyoatrial structure of the skin present at the fingertips and involved in thermoregulation. The literature historically considered these tumors isolated and sporadic, but some studies have proved a relationship with neurofibromatosis type I. Thus, patients with neurofibromatosis type 1 should be investigated. The case report provides additional support for the notion that NF1 has a risk associated with multiple glomus tumors.

Keywords: Glomus Tumor; Association; Case Reports; Neoplasms; Neurofibromatoses

Squamous cell carcinoma (SCC) has the second highest incidence rate among non-melanoma skin cancers. About 5% of cases progress to locally advanced and/or metastatic lesions, making the surgical approach often unfeasible. Based on this, we performed a literature review on the use of immunotherapy drugs to treat advanced SCC. The results showed that immunotherapy is a potential therapeutic strategy due to the antitumor activity promotion through the individual immune response, reducing the adverse events of surgeries, chemotherapy, and radiotherapy

Keywords: Squamous cell carcinoma; Tumor Evasion; Immunotherapy; Skin neoplasms

Schwannomas are benign nerve sheath tumors derived from Schwann cells. The sites most often involved are the head and neck (25-48%), with only 1% occurring in the oral cavity. Most schwannomas occur in adult individuals between the third and fifth decades of life. Lip involvement is extremely rare during childhood and adolescence, with few reports in the literature. The prognosis is favorable and surgical excision is the treatment of choice. We report an interesting case of upper lip schwannoma in an adolescent with successful surgical treatment and no evidence of recurrence after 4 years.

Keywords: Neurilemmoma; Lip; Neoplasms; Schwann Cells.

O fibroxantoma atípico (FXA) é um tumor mesenquimal raro que geralmente acomete pacientes com idade avançada, do sexo masculino, em áreas fotoexpostas. É mais frequente na cabeça e pescoço, mas também pode ocorrer no tronco e nas extremidades. Atualmente, é considerado um tumor benigno de diagnóstico por exclusão, com baixa taxa de recidiva e metástase. O tratamento é realizado com excisão cirúrgica, o que permite o diagnóstico por avaliação histológica e imuno-histoquímica.

Keywords: Tórax; Oncologia Cirúrgica; Dermoscopia; Neoplasias; Imuno-Histoquímica; Sarcoma

Granular cell tumors are rare neurogenic neoplasms, usually benign, with a nonspecific clinical presentation. We report the case of a 70-year-old woman with an ulcerated nodular lesion on the arm, showing progressive growth, pain, and pruritus. Findings from complementary examinations, including magnetic resonance imaging, histopathological examination, and immunohistochemistry, confirmed, respectively, an expansive subcutaneous mass, a proliferation of polyhedral cells with granular cytoplasm, and positivity for the S100 protein, consistent with a diagnosis of granular cell tumor. The report discusses the importance of early diagnosis, complete surgical excision, and clinical follow-up to prevent recurrences and to monitor the rare risk of malignancy.

Keywords: Granular Cell Tumor; Schwann Cells; Neoplasms by Site