Keratoacanthoma may be easily mistaken with squamous cell carcinoma, both clinically as well as histopathologically. However, only keratoacanthoma can regress spontaneously.We report a case of a patient with a exophytic, ulceraded, infiltrated lesion in their scalp that was initially diagnosed as a keratoacanthoma. The histopathologic examination confirmed the presence of squamous cell carcinoma, and the tomography of the skull showed that the cancer had spread within the cranium. A surgical excision with wide margins and rotation flap was conducted, followed by adjuvant chemotherapy and radiotherapy treatments.There are a great number of accounts of squamous cell carcinoma erroneously diagnosed as keratoacanthomas in the specialist literature, illustrating the difficulty in differentiating between them.While there is no established effective method to distinguish between the two conditions, surgical excision should be the treatment of choice.

Keywords: CARCINOMA, SQUAMOUS CELL, KERATOACANTHOMA, SURGERY

Introduction: Mohs Micrographic Surgery is a well-known and established method in the United States, and is currently considered the gold standard treatment in many cases involving cutaneous neoplasias. Since it was first described by Dr. Frederic E. Mohs, the micrographic surgery technique has been continuously changed and adapted to better suit the daily life needs of dermatologic surgeons. This article examines different and innovative Mohs Micrographic Surgery techniques.

Keywords: MOHS SURGERY, CARCINOMA, BASAL CELL, CARCINOMA, SQUAMOUS CELL

A case of pigmented basocellular carcinoma clinically mimicking a malignant lentigo melanoma in the temporal region of a black female patient is reported. Basal cell carcinoma rarely occurs in black patients. When present, however, it is the second most common malignant skin neoplasia, and is usually pigmented. When the face is affected in such patients, it is difficult to differentiate between malignant lentigo melanoma and basal cell carcinoma. Dermatoscopy is a very helpful diagnostic tool in these cases.

Keywords: CARCINOMA, BASAL CELL, MELANOMA, DERMOSCOPY

Dermoscopy is increasingly used to diagnose non-melanocytic skin tumors. Basal cell carcinoma presents some highly suggestive structures for its diagnosis. The presence of chrysalides-like structures is also frequently found in other benign and malignant skin tumors, and their significance in basal cell carcinoma has yet to be determined. HPV is a virus with oncogenic potential and its involvement in the pathogenesis of basal cell carcinomas is also not yet clearly understood.

Keywords: CARCINOMA, BASAL CELL, DERMOSCOPY, ONCOGENES

Merkel cell carcinomas are highly aggressive neuroendocrine skin tumors that have a poor prognosis. The authors present a case report and emphasize the importance of early diagnosis and treatment.

Keywords: CARCINOMA, MERKEL CELL, IMMUNOHISTOCHEMISTRY, SKIN

Introduction: The reconstruction of surgical defects resulting from the excision of tumors in the nose is a challenge for dermatologic surgeons due to its rigid structure and low mobility. The Mohs Micrographic Surgery technique allows the preservation of healthy tissue and leads to a smaller surgical wound. Objective: To demonstrate techniques for surgical correction of defects after removal of tumors of the nose through Mohs Micrographic Surgery, according to the anatomical location of the tumor. Methods: Descriptive study of patients operated on using Mohs Micrographic Surgery during the period 1996-2010. Patient images taken pre-, intra-, and post-operatively were analyzed with the aim of classifying the defect's anatomic location and the type of surgical reconstruction adopted. Results: 170 patients (totaling 203 lesions) were included in the study. The most common locations for tumors were (in descending order): nasal ala, dorsum, tip, and lateral wall. The advancement flap was the most common reconstruction type for lesions located in the lateral wall and in the nasal ala. Grafts were most often used in lesions located in the tip of the nose. Grafts and advancement flaps were more frequently used in the dorsum of the nose. Conclusions: The parameters that provide guidance on choosing the best reconstruction method must take into consideration the size and location of the surgical defect.

Keywords: MOHS SURGERY, CARCINOMA, BASAL CELL, CARCINOMA, SQUAMOUS CELL

Introduction: Mohs micrographic surgery is a treatment option that increases the cure rate in various types of skin cancer, offering greater tissue preservation and lower recurrence rates. Objective: To describe clinically and histologically the tumors operated on with Mohs micrographic surgery, and to draw correlations to the number of stages and the type of surgical reconstruction performed. The operations were performed at a private clinic in the municipality of Rio de Janeiro, Brazil that is a specialist center for this technique. Methods: Retrospective, observational, cross-sectional/transversal study was carried out based on the review of medical records. Results: A study was conducted of 93 tumors in 84 patients, operated on between April 2010 and August 2012, and followed up with until August 2013 (12 to 42 months). Findings: 47.61% of patients were men and 52.38% were women, the mean age was 62.89 years; predominant phototypes: II (44%) and III (43%); 6 cases (6.45%) of squamous cell carcinoma, 87 (93.54%) of basal cell carcinoma; 74.19% were primary tumors; the nose was the most frequent site (46.24%); a single surgical stage was performed in most cases, with flaps (44%) being the more frequently performed type of closure. There was recurrence in one patient, who required reoperation in October 2012 and followed without new recurrence. Conclusions: Mohs surgery has proven effective with high cure rates and a minimal recurrence rate, especially in lesions located in the face's H area of risk.

Keywords: MOHS SURGRY, CARCINOMA, BASAL CELL, CARCINOMA, SQUAMOUS CELL.

Squamous cell carcinoma is related to exposure to UVB radiation and the presence of chronic cutaneous lesions. Folliculitis decalvans is a cicatricial alopecia that develops with the inflammation of the scalp. In the medical literature, the association between folliculitis decalvans and squamous cell carcinoma is rare, a factor motivating this report. A 66-year-old male patient, bearer of folliculitis decalvans since childhood, complained of progressive growth of lesions in the alopecia area. The biopsy confirmed squamous cell carcinoma. This case report covers the concept of "Marjolin ulcer" for including folliculitis decalvans as inflammatory lesion precursor of squamous cell carcinoma.

Keywords: ALOPECIA; CARCINOMA, SQUAMOUS CELL; FOLLICULITIS

Basal cell carcinoma is the most common type of cancer and its non-surgical treatment has been the subject of many studies. Large lesions of this tumor are therapeutic challenges and the effective topical treatment has good applicability. The authors present a female patient diagnosed with multicentric superficial basal cell carcinoma in the lumbar region for more than 20 years, who refused to be treated surgically. The tumor reached dimensions of 12 cm x 10 cm. A decision was made for a non-surgical therapy, with the application of Imiquimod in a treatment of 5 weekly applications for 2 months. The treatment led to a clinical and histological cure, without recurrence to date (36 months), with excellent aesthetic results and few side effects.

Keywords: CARCINOMA, BASAL CELL; THERAPEUTICS; NEOPLASMS

INTRODUCTION: Basal cell carcinoma (BCC) is the most common cancer in the world. Although rarely metastasizes, BCC can cause high levels of morbidity due to its locally destructive nature. Local flaps provide reasonable option for reconstruction of facial defects with good result.
OBJECTIVE: Describe the clinical profile of BCC in South Sulawesi, Indonesia.
METHODS: A retrospective analysis was performed in all patients with BCC who had undergone surgical resection in our center. Patient charts were reviewed for demographic information, tumor size, anatomic location, clinical subtype, and surgical method.
RESULTS: There were 70 BCC cases consisting of 18 (25.7%) men and 52 (74.3%) women. The most frequent age group was 46 to 65-year-old group (49 patients, 70%). The most common aesthetic unit affected was the nasal unit (24 patients, 34.3%) with lesions measured 1 cm to 2 cm in diameter (45 patients, 64.29%). The most common clinical subtype was nodular type (37 patients, 52.86 %). Advancement flap was the most frequent technique used (32 patients, 45.71%).
CONCLUSIONS: BCC more frequently occurs in females, on the nose, and in the age range of 46 to 64 years old. Local flaps resulted in an excellent aesthetic result and are the first choice for reconstruction of the face.

Keywords: Basal cell; Carcinoma; Retrospective studies; Surgical flaps

The cuniculatum carcinoma is a rare, slow-growth, local aggressive subtype of the squamous cell carcinoma, presented as a verrucous lesion with a low metastasis capacity. Its histopathology shows keratin-filled crypts, and its etiology is linked with HPV, especially 11 and 16 subtypes. The treatment of choice is surgical excision, followed by regular monitoring due to the high risk of local recurrence. We report a case of a woman with Cuniculatum carcinoma treated with surgery with perioperative frozen section procedure, graft, and good evolution.

Keywords: Carcinoma; Carcinoma, Squamous Cell; Foot

O queratoacantoma (QA), apesar de frequente na prática diária, é um tumor que gera questionamentos. O aspecto mais intrigante associa-se à sua posição no limite entre malignidade e benignidade. A abordagem do tumor, bem como sua classificação, é controversa. Na definição da conduta, é importante levar em conta o potencial de transformação para carcinoma espinocelular. Desse modo, a excisão cirúrgica é a terapia de escolha, sempre que possível. Algumas situações merecem atenção adicional, como a imunossupressão associada. Neste artigo, relatamos um caso de QA gigante em um paciente com síndrome da imunodeficiência adquirida tratado com cirurgia micrográfica de Mohs.

Keywords: Ceratoacantoma; Retalhos Cirúrgicos; Neoplasias Nasais; Neoplasias Cutâneas; Cirurgia de Mohs; Síndrome de Imunodeficiência Adquirida; HIV; Imunossupressão

Sarcomas são neoplasias mesenquimais malignas, raras, que acometem, principalmente, crianças e adolescentes. O rabdomiossarcoma, subtipo oriundo da musculatura esquelética, é condição incomum em adultos, acometendo sítios de localização não habitual, crescimento rápido e de difícil tratamento. Apresenta-se caso de adulto jovem com nodulação em lóbulo auricular esquerdo, cuja análise histopatológica e imuno-histoquímica confirmou tratar-se de rabdomiossarcoma alveolar, o qual foi conduzido em conjunto com a Oncologia.

Keywords: Rabdomiossarcoma Alveolar; Miogenina; Desmina; Excisão de Linfonodo

INTRODUCTION: Actinic keratoses are premalignant lesions with a risk of transformation to invasive squamous cell carcinoma. There is no identified correlation between clinical classification and histological grade of these lesions.
OBJECTIVES: To correlate the clinical characteristics of actinic keratoses of the forearms and back of the hands with the degree of histological atypia (Keratinocyte Intraepidermal Neoplasia); to develop and validate a clinical severity scale correlated with the histological grade of actinic keratoses.
METHODS: Cross-sectional study with 162 actinic keratoses clinically evaluated for diameter, erythema, infiltration, hyperkeratosis, and exulceration and 34 lesions with different patterns were biopsied. Clinical features were correlated with the degree of histological atypia and p53 and Ki-67 expression.
RESULTS: Only the diameter of the lesions was significantly correlated with the degree of atypia (p=0.04), and only the erythema, hyperkeratosis, and the diameter linked with the immunohistochemical markings. A clinical score including diameter, hyperkeratosis, and exulceration was developed, which associated significantly with the degree of atypia (Spearman’s Rho=0.43; p=0.01).
CONCLUSIONS: A score composed of diameter, hyperkeratosis, and exulceration correlated with the histological grade of actinic keratoses of the upper limbs was developed.

Keywords: Carcinoma in situ; Carcinoma squamous cell; Keratosis actinic; Skin diseases

The preservation of the surgical margins marking is essential during Mohs micrographic surgery. However, skin degermation during antisepsis and the use of gauze during local anesthesia often remove these markings. The use of the protective film Cavilon^® 3M to fix the marking pen ink was effective in preserving the surgical map, allowing an accurate removal of the surgical specimen.

Keywords: Mohs surgery; Carcinoma, Basal cell; Carcinoma, Squamous cell; Excision Margins