Introduction: Androgenic alopecia is a progressive alteration of the scalp with few treatment options, which motivates the search for new local or systemic medications to control this pathology.
Objective: To evaluate patient tolerance for and identify the action mechanism of the Cellium® GC compound in the treatment of androgenic alopecia.
Methods: Male patients (n = 20) with androgenic alopecia participated in this open prospective study. The compound was used on the scalp twice a day, at home, for 12 con- secutive weeks. Biopsies were carried out before and after treatment to evaluate the alterations in the cutaneous immune response, cellular proliferation and anti-apoptosis activity. Questionnaires were administered to evaluate efficacy and patient satisfaction.
Results: Nineteen patients completed the study, with an average satisfaction of 8.3 out of 10. Immunohistochemical analyses of scalp biopsies showed a significant increase in the cutaneous immune response after treatment: 73.9% increase in CD1A+ Langerhans cells (p = 0.003, t paired test), 41.7% increase in the cellular proliferation marker Ki-67+ (p = 0.012), and an 89% increase in BCL-2+ anti apoptotic proteins (p = 001). The product was also found to be tolerable and safe.
Conclusions: Cellium® GC improved the skin''''''''s immune defense and the proliferation of keratinocytes, and produced high levels of patient satisfaction in the treatment of androgenic alopecia.

Keywords: ALOPECIA, BIOPSY, KERACINOCYTES, MINOXIDIL

In hair transplants, the donor area can supply only a limited number of follicular units in each procedure. In the treatment of more advanced degrees of baldness, removing both a scalp strip and follicular units, one by one, is an option that allows more units to be harvested in a single session, thus providing a better density and coverage of the bald area. This article describes a technique called Untouched Strip, which, in addition to increasing the number of follicular units with the combined procedure, preserves the donor area for a possible future transplant.

Keywords: HAIR, TRANSPLANTATION, ALOPECIA

Zoon''''''''s balanitis is a benign chronic inflammatory lesion of unknown etiology. This article reports the case of a 66-year-old male patient who presented a 2-year history of a erythematous plaque located on the glans penis. The lesion had not been very responsive to conservative topical treatment with corticoid. A significant reduction in the plaque''''''''s size and an improvement in the pruritus was observed with the use of fractional CO2 laser combined with fusidic acid. The treatment was well tolerated and easy to carry out, and improved the patient''''''''s quality of life.

Keywords: PLASMA CELLS, LASER THERAPY, FUSIDIC ACID

Treatment of folliculitis decalvans is a major challenge, with a great number of recurrences and required maintenance of disease activity over a long period. Laser-based hair removal has been used in the management of scarring follicular disorders. The present case report aims to illustrate the case of a patient bearing folliculitis decalvans in the lower limb who underwent five therapeutic sessions of neodymium:YAG laser (Nd:YAG), achieving complete remission of the inflammatory lesions with the treatment.

Keywords: FOLLICULITIS, LASER THERAPY, DERMATOLOGY, ALOPECIA

Introduction: Telogen effluvium is a chronic progressive alopecia of multifactorial etiology. Nutritional deficiency-sometimes subclinical-can trigger it. Objective: To evaluate the influence of a nutritional supplementation at physiological doses in patients with telogen effluvium. Methods: The supplementation of nutrients in food doses was carried out in 60 female patients for 180 days. Results: There was a significant improvement (p <0.05) in hair loss, which was confirmed by digital phototrichogram, where there was a significant increase in anagen hairs and reduction of telogen hairs. Conclusion: The present study demonstrated that in cases of telogen effluvium without an apparent cause, the replenishment of nutrients related to the hair cycle has a significant benefit in the regression of the picture as soon as after three months of treatment.

Keywords: ALOPECIA; NUTRIENTS; HAIR.

Introduction: Introduction: Androgenic alopecia is the most common type of alopecia. It is characterized by alterations in the hair cycle, leading to progressive follicular miniaturization. Platelet-rich plasma, promotes angiogenesis in the tissue by action of growth factors, which stimulate the hair follicle Objective: To eveluate the hair growth in androgenic alopecia, through cell stimulation performed with the subcutaneous injection of platelet-rich plasma. Methods: Three injections of platelet-rich plasma were performed in 18 patients, at 21-day intervals.The evaluation was performed through comparative clinical photographs, dermoscopy, as well from responses to questionnaires. The Mann-Whitney test and Wilcoxon test were used to analyze the results. Results: For seven women who completed the study, the average improvement was 42.85% (patients) and 35.71% (external observer). For the 9 males, the average improvement was 25.55% (patients) and 18.88% (external observer). In Dermoscopy were observed thickening of hairs, improved local circulation and increased number of follicles. Conclusions: An effective and satisfactory response in androgenic alopecia was verified in relation to the platelet-rich plasma injection technique.

Keywords: ALOPECIA; PLATELET-RICH PLASMA; DERMATOLOGY

Introduction: Male androgenetic alopecia, has high prevalence and causes great discomfort in patients. The platelet-rich plasma generates an environment acts to create a suitable microenvironment for tissue repair and possibly prolongs the anagen phase of the hair follicles.
Objective: To evaluate the safety, efficacy and viability of the PRP use for the treatment of male androgenetic alopecia. Methods: We selected 08 male patients with androgenetic alopecia. Participants had the side of the scalp randomized scalp to receive PRP or placebo. 3 were performed monthly applications.
Results: Patients who received treatment realized some degree of improvement especially as regards the fall. The results were obtained through the analysis dermatoscopic was evaluated as "trichoscale". We observed an increase of anagen hairs, down telogen hairs and vellus wires and increase terminal wires. The results were statistically significant as the reduction of vellus wires and increase of terminals wires.
Conclusions: This study showed a clinical improvement observed for photos as well as positive results documented by analysis "trichoscale". There was statistical significance of data obtained especially after the first month of treatment.

Keywords: ALOPECIA; PLATELET-RICH PLASMA; MEN

Alopecia areata can cause significant psychological problems due to the unpredictable nature of the disease, which results in hair loss. We report the case of a patient presenting alopecia areata of difficult treatment, with satisfactory response after intralesional applications of corticosteroid, but that showed recurrence and atrophy; it was then decided to perform intralesional applications of platelet-rich plasma, with improvement of the condition. The technique showed good results in this isolated case, proving to be a potentially useful therapy in the treatment of alopecia areata.

Keywords: ALOPECIA AREATA; ADRENAL CORTEX HORMONES; PLATELET-RICH PLASMA

Introduction: Acne is a multifactorial disease where inflammatory lesions usually appear as papules, pustules and comedones. It is more common in people aged between 11 and 30 years, and occurs in various body sites where there are high concentrations of pilosebaceous glands. Acne has different classifications and treatments. More recently, platelet growth factors have been used as an alternative therapy for acne scars.
Objective: The present study is aimed at describing a case of nodule-cystic acne and acne scars Grades 1, 2 and 3b treated with platelet rich plasma and highlighting the effectiveness of the treatment.
Methods: Platelet rich plasma was applied for three months in the left side of the face of a patient bearing acne.
Results: In the clinical and photographic evaluations, there was improvement in the skin appearance and quality, less number of lesions and decrease of pain.
Conclusions: The present study has demonstrated the effectiveness of platelet rich plasma as a treatment for acne and resulting scars.

Keywords: PLATELET-RICH PLASMA; ACNE VULGARIS; CICATRIX

Alopecia areata is a chronic condition of hair follicles and nails with unknown etiology, which causes hair loss. It emerges in several clinical types, with the diffuse form, where there is acute and diffuse hair loss, being atypical. It is generally accepted that there is a T-cell mediated, organ-specific autoimmune base in alopecia areata and studies indicate that the autoantigen is associated with melanocytes. The authors of the present paper report the case of a patient who had the diffuse form of alopecia areata, with preservation of the gray hair strands

Keywords: Alopecia Areata; Alopecia; Autoantigens; Hair

Microneedling or Percutaneous Collagen Induction is a minimally invasive dermatological procedure that utilizes needles to create orifices or in the skin. Its aim is to induce collagen formation, neovascularization and production of growth factors. There is increased demand because it is a relatively simple procedure, cost-effective, safe and that yields satisfactory results. It treats localized areas and studies are being done to evaluate its role in inflammation, dyspigmentation, and photodamage. The therapeutic use includes the treatment of acne scars, stretch marks, wrinkles, melasma, hyperhidrosis, alopecia. Lately, it has been used for the transepidermal distribution of active compounds and vaccines.

Keywords: Acne vulgaris; Alopecia; Collagen rejuvenation; Dermatologic surgical procedures; Percutaneous collagen induction; Treatment outcome; Wound healing

Janus kinase inhibitors have changed the therapeutic paradigm of severe alopecia areata therapy. Some patients are refractory to dosage escalating. In this article, we describe the applicability of adjuvant oral minoxidil therapy.

Keywords: Alopecia; Alopecia Areata; Hair Janus Kinases; Minoxidil

A Covid-19, doença causadora de síndrome gripal e insuficiência respiratória aguda, vem demonstrando provocar danos a diversos outros órgãos e sistemas. Várias manifestações dermatológicas já foram descritas. Relatamos um quadro de alopecia areata (AA) desencadeada possivelmente pela Covid-19 em paciente que, apesar de ter seu RT-PCR para SARS-CoV-2 negativo, apresentou IgM reagente e sintomatologia clássica relacionada à doença. Acreditamos que a Covid-19 possa ter desencadeado resposta imunológica autoimune, com a consequente produção de interferons, que levou ao quadro de AA.

Keywords: Alopecia em áreas; Autoimunidade; Coronavirus

The present study is a scientometric analysis aiming to verify the scientific production about radiofrequency in facial wrinkles. The databases used were the Web of Science and Pubmed. We searched the literature for all articles with the terms "Radiofrequency", "Facial", and "Wrinkle" in the title, abstract, or keywords. For each study, we analyzed the following scientometric indicators: publication number per year, name of the journal, authors, impact factor, country of publication, and type of study.

Keywords: Aging; Aesthetic equipment; Plasma

Histological data on microscopic treatment zones are essential for evaluating procedure safety and effectiveness. To date, no studies have histologically compared low-temperature plasma with other techniques. In this study, two square areas on the patient's abdomen, referred to as area A and area B, were with low-temperature plasma and fractional CO2 laser, respectively. A biopsy was taken immediately after treatment. When applied to thinner skin regions, plasma technology appears to result in fewer complications, a faster recovery, and fewer side effects during the application period. However, further studies are needed to confirm these findings.

Keywords: Laser Therapy; Histology Comparative; Plasma Skin Regeneration; Gas Lasers.