Introduction: Cutaneous aging affects (or will affect) all people at some point in their life, and its treatment represents a clinical challenge.
Objective: To evaluate the cutaneous effects of an oral supplement based on marine protein, concentrated acerola and extracts of grape seed and tomato in women with cutaneous aging.
Methods: Forty-five volunteers used 2 daily tablets of the supplement for 360 consecutive days. Clinical evaluations (carried out by both the investigator physicians and by the volunteers), ultrasonographic and photographic examinations were carried out every 30 days.
Results: Thirty-three volunteers (73.3%) completed the study. Clinically significant improvement was verified by the investigator physicians and the volunteers after 30 days of using the oral supplement (p < 0.05). The results were maintained after 330 days (p ¿ 0.05). The ultrasonographic analysis demonstrated increases in the dermal density of the photoexposed (132.3%; p < 0.001) and photoprotected areas (51.9%; p ¿ 0.001). Through medical analysis, statistically significant improvements were found in the following criteria: wrinkles, fine lines, solar melanoses, other hyperchromias, erythema, hydration, radiance , sebum, smoothness and overall appearance of the skin. Through the volunteers'''''''' self-evaluation, improvements in the wrinkles'''''''' pattern, fine lines, solar melanoses, other hyperchromias, erythema, hydration, radiance, sebum, smoothness and overall appearance of the skin were reported.
Conclusion: The long-term use (360 days) of an oral supplement based on marine protein, concentrated acerola and extracts of grape seed and tomato was proven to be a good adjuvant systemic approach for treating cutaneous aging.

Keywords: SKIN AGING, DIETARY SUPPLEMENTS, VITAMIN C, GRAPE SEED EXTRACT

Introduction: The use of nutraceutical products in order to attenuate signs of skin aging has been proposed in the literature. The stimulus to the synthesis of substances that support the dermis is one of the mechanisms linked to this effect.
Objective: To evaluate the effectiveness of a nutraceutical compound containing lutein, lycopene, vitamin C and manganese for the synthesis of collagen, elastin and hyaluronic acid.
Methods: An in vitro study was carried out based on the culture of human fibroblasts treated with the investigated product in different non-cytotoxic concentrations. The quantification of the elastin and collagen was performed with the assistance of spectrophotometric measurements. Hyaluronic acid was measure using a immunoenzymatic method.
Results: Cell cultures treated with the different concentrations of the product showed a significantly higher amount of synthesized collagen, elastin and hyaluronic acid as compared to the untreated culture (p <0.05).
Conclusions: The use of the nutraceutical compound containing lycopene, vitamin C, lutein and manganese has shown in vitro efficacy for stimulating the synthesis of collagen, elastin and hyaluronic acid, components that are crucial for providing the dermis' supporting structure, being responsible for the skin's firmness and elasticity.

Keywords: DERMATOLOGY; DIETARY SUPPLEMENTS; SKIN AGING

Introduction: The use of nutraceutical products in the treatment of chronic telogen effluvium of non-specific cause – associated or not with signs and symptoms of nail plate frailty – has been proposed in the literature. Supplementation of nutrients and trace elements that are crucial to follicle’s metabolism seems to be linked to this effect.
Objective: To evaluate the efficacy of a nutraceutical containing vitamins A, C, E and B complex, folic acid, iron, niacin, biotin, zinc and calcium pantetonate, among others, in the treatment of telogen effluvium associated with the brittle nails syndrome.
Methods: A clinical, prospective, open and monocentric study was carried out with the evaluation of 62 volunteers. Clinical evaluation measurements – based on digital phototrichogram and imaging – were performed at the baseline, and at 45 and 90 days after the use of the studied product.
Results: At the end of the study, a statistically significant (p <0.05) reduction of 31.56% in the number of telogen strands could be observed, coupled with a significant improvement in clinical parameters related to hair and nails. The instrumental evaluation based on image analysis showed a 36.63% reduction in nail desquamation, which, although not statistically significant, has shown benefits in the absolute outcome.
Conclusions: The use of nutraceuticals was proven effective in the treatment of telogen effluvium associated with the brittle nails syndrome.

Keywords: Alopecia; Dietary supplements; Nails

INTRODUCTION: The term inflammaging refers to the increase of the inflammatory response due to aging, resulting in a low level chronic pro-inflammatory state. High levels of proinflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor occur. Thus, the use of active principles that modulate the inflammatory response assists in the reduction of cellular oxidative stress, also reducing or avoiding irreversible cellular and non-clinically detectable molecular damage.
OBJECTIVE: To evaluate the action of a compound containing collagen peptides, Delphinol^®, vitamin C and hibiscus on the modulation of the cutaneous inflammatory response.
SUPORTE FINANCEIRO: Laboratório Farmoquímica, Rio de Janeiro - RJ, Brasil. Conflito de Interesses: Os autores afirmam não possuir interesses pessoais, comerciais, políticos ou financeiros neste manuscrito.
MATERIALS AND METHODS: The release of inflammatory cytokines after treatment with the product was evaluated in keratinocytes exposed to an inflammatory response-inducing lipopolysaccharide.
RESULTS: When keratinocytes were exposed to the studied compound, it was possible to observe an increase in the release of interleukin 6 and a reduction tendency in the levels of interleukin 1-alpha and interleukin-8. In addition, the release of basal tumor necrosis factor-alpha was reduced by 67.5% (P = 0.008).
CONCLUSIONS: The compound studied has a potential effect on inflammaging — and consequently on aging — by modulating the inflammatory cytokines interleukin-1 alpha, interleukin-6, interleukin-8 and tumor necrosis factor-alpha.

Keywords: Aging; Anti-Inflammatory agents; Antioxidants; Ascorbic acid; Collagen; Dietary Suplements; Hibiscus; Inflammation mediators; Skin; Skin aging

O queratoacantoma (QA), apesar de frequente na prática diária, é um tumor que gera questionamentos. O aspecto mais intrigante associa-se à sua posição no limite entre malignidade e benignidade. A abordagem do tumor, bem como sua classificação, é controversa. Na definição da conduta, é importante levar em conta o potencial de transformação para carcinoma espinocelular. Desse modo, a excisão cirúrgica é a terapia de escolha, sempre que possível. Algumas situações merecem atenção adicional, como a imunossupressão associada. Neste artigo, relatamos um caso de QA gigante em um paciente com síndrome da imunodeficiência adquirida tratado com cirurgia micrográfica de Mohs.

Keywords: Ceratoacantoma; Retalhos Cirúrgicos; Neoplasias Nasais; Neoplasias Cutâneas; Cirurgia de Mohs; Síndrome de Imunodeficiência Adquirida; HIV; Imunossupressão

Sarcomas são neoplasias mesenquimais malignas, raras, que acometem, principalmente, crianças e adolescentes. O rabdomiossarcoma, subtipo oriundo da musculatura esquelética, é condição incomum em adultos, acometendo sítios de localização não habitual, crescimento rápido e de difícil tratamento. Apresenta-se caso de adulto jovem com nodulação em lóbulo auricular esquerdo, cuja análise histopatológica e imuno-histoquímica confirmou tratar-se de rabdomiossarcoma alveolar, o qual foi conduzido em conjunto com a Oncologia.

Keywords: Rabdomiossarcoma Alveolar; Miogenina; Desmina; Excisão de Linfonodo

In the aging process, the intracellular routes that regulate collagen homeostasis are influenced by the exposome, resulting in its degradation and decreased synthesis, leading to sagging skin. Current evidence indicates that oral collagen supplementation may promote wrinkles reduction in the eye area, wound healing, skin elasticity and hydration improvement, enhancement of cellulite, some dermatitis, and nails fragility. Large-scale and methodologically more robust studies are still needed to consider the use of oral collagen as an effective adjuvant treatment to different dermatological conditions.

Keywords: Collagen; Skin; Dietary supplements

INTRODUCTION: Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense, seems to be the main process that worsens skin aging, and the mitochondria is an important source of ROS. There is increasing evidence that oral administration of functional nutrients can protect the skin from oxidative damage.
OBJECTIVE: To evaluate the effectiveness of an oral supplement with collagen peptides and other nutrients in reducing the signs of photoaging.
METHODS: In vitro studies evaluated the antioxidant and antiglycant effects under UV light, as well as the synthesis of extracellular dermal matrix components; then, a clinical trial was developed with women between 35 and 60 years old, for 12 weeks. Hydration (corneometry) and skin firmness (cutometry) measurements were performed.
RESULTS: The supplement showed antioxidant and antiglycant properties under the stress generated by UV radiation, as well as the ability to induce synthesis of extracellular dermal matrix elements; There was an improvement in all clinical parameters of aging. Significant improvement in hydration and firmness and elasticity were also observed.
CONCLUSION: Collagen peptides and nutrients association demonstrated an effect in some mechanisms involved in the photoaging process, leading a clinical improvement.

Keywords: Collagen; Exposome; Oxidation; Skin Aging; Glycation End Products, Advanced; Dietary Supplements.