In vitro evaluation of the anti-inflammatory activity of an oral administration product containing collagen peptides, Delphinol^®, vitamin c and hibiscus

Abstract

INTRODUCTION: The term inflammaging refers to the increase of the inflammatory response due to aging, resulting in a low level chronic pro-inflammatory state. High levels of proinflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor occur. Thus, the use of active principles that modulate the inflammatory response assists in the reduction of cellular oxidative stress, also reducing or avoiding irreversible cellular and non-clinically detectable molecular damage.
OBJECTIVE: To evaluate the action of a compound containing collagen peptides, Delphinol^®, vitamin C and hibiscus on the modulation of the cutaneous inflammatory response.
SUPORTE FINANCEIRO: Laboratório Farmoquímica, Rio de Janeiro - RJ, Brasil. Conflito de Interesses: Os autores afirmam não possuir interesses pessoais, comerciais, políticos ou financeiros neste manuscrito.
MATERIALS AND METHODS: The release of inflammatory cytokines after treatment with the product was evaluated in keratinocytes exposed to an inflammatory response-inducing lipopolysaccharide.
RESULTS: When keratinocytes were exposed to the studied compound, it was possible to observe an increase in the release of interleukin 6 and a reduction tendency in the levels of interleukin 1-alpha and interleukin-8. In addition, the release of basal tumor necrosis factor-alpha was reduced by 67.5% (P = 0.008).
CONCLUSIONS: The compound studied has a potential effect on inflammaging — and consequently on aging — by modulating the inflammatory cytokines interleukin-1 alpha, interleukin-6, interleukin-8 and tumor necrosis factor-alpha.

Keywords: Aging; Anti-Inflammatory agents; Antioxidants; Ascorbic acid; Collagen; Dietary Suplements; Hibiscus; Inflammation mediators; Skin; Skin aging

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