INTRODUCTION: Melasma is an acquired pathology secondary to hypermelanosis, recurrent, and often refractory to therapy, despite several treatment options. Microneedling is mainly indicated for refractory cases since it is an invasive method with the mechanism of action not yet fully understood for this indication.
OBJECTIVE: To compare the response to melasma treatment between a group that received only microneedling and another treated with microneedling combined with drug delivery.
METHODS: Twenty patients participated in the study: seven received only microneedling and 13 received microneedling followed by drug delivery of lightening serum in three sessions, with monthly intervals. The results between the groups were compared regarding improvement of the Melasma Area and Severity Index (MASI), texture and reduction of skin pore diameter; presence of erythema, crusting and peeling; improvement of melasma extension and tone.
RESULTS: The group that received microneedling combined with drug delivery had the most favorable results in improving texture, decreasing skin pore diameter, and improving melasma extension and tone. MASI improvement occurred in both groups, in similar percentages.
CONCLUSIONS: According to the present study, both therapies are promising for melasma treatment.

Keywords: Comparative study; Therapeutic approachs; Treatment outcome; Evaluation of results of therapeutic interventions

O queratoacantoma (QA), apesar de frequente na prática diária, é um tumor que gera questionamentos. O aspecto mais intrigante associa-se à sua posição no limite entre malignidade e benignidade. A abordagem do tumor, bem como sua classificação, é controversa. Na definição da conduta, é importante levar em conta o potencial de transformação para carcinoma espinocelular. Desse modo, a excisão cirúrgica é a terapia de escolha, sempre que possível. Algumas situações merecem atenção adicional, como a imunossupressão associada. Neste artigo, relatamos um caso de QA gigante em um paciente com síndrome da imunodeficiência adquirida tratado com cirurgia micrográfica de Mohs.

Keywords: Ceratoacantoma; Retalhos Cirúrgicos; Neoplasias Nasais; Neoplasias Cutâneas; Cirurgia de Mohs; Síndrome de Imunodeficiência Adquirida; HIV; Imunossupressão

Sarcomas são neoplasias mesenquimais malignas, raras, que acometem, principalmente, crianças e adolescentes. O rabdomiossarcoma, subtipo oriundo da musculatura esquelética, é condição incomum em adultos, acometendo sítios de localização não habitual, crescimento rápido e de difícil tratamento. Apresenta-se caso de adulto jovem com nodulação em lóbulo auricular esquerdo, cuja análise histopatológica e imuno-histoquímica confirmou tratar-se de rabdomiossarcoma alveolar, o qual foi conduzido em conjunto com a Oncologia.

Keywords: Rabdomiossarcoma Alveolar; Miogenina; Desmina; Excisão de Linfonodo

Histological data on microscopic treatment zones are essential for evaluating procedure safety and effectiveness. To date, no studies have histologically compared low-temperature plasma with other techniques. In this study, two square areas on the patient's abdomen, referred to as area A and area B, were with low-temperature plasma and fractional CO2 laser, respectively. A biopsy was taken immediately after treatment. When applied to thinner skin regions, plasma technology appears to result in fewer complications, a faster recovery, and fewer side effects during the application period. However, further studies are needed to confirm these findings.

Keywords: Laser Therapy; Histology Comparative; Plasma Skin Regeneration; Gas Lasers.