Surg Cosmet Dermatol. 2014;6(4):338-343
Introduction: Injectable hyaluronic acid is regarded as the gold standard treatment in the aesthetic correction of wrinkles, loss of contour, and restoration of facial volume. However, it is expected that consequentially adverse - sometimes severe - reactions will arise concomitant with the growth in use of hyaluronic acid-based cutaneous fillers.
Objective: To evaluate the application of hyaluronidase in the treatment of adverse effects of injectable hyaluronic acid, as well as possible reactions to the intradermal injection of that enzyme.
Methods: A retrospective study was carried out with 50 patients who underwent the application of hyaluronidase aimed at correcting complications or unaesthetic effects following hyaluronic acid-based filling procedures in the face.
Results: Twenty-three patients had some type of adverse effect (restricted to the injection site) ranging from erythema, burning sensations, and mild edema, during or after the application, with spontaneous improvement. There were no cases of moderate to severe edema. Most patients reported regression of excess hyaluronic acid a few hours after the injection.
Conclusions: Hyaluronidase is an extremely effective tool both in acute adverse events and in the reversal of unsatisfactory results, and in the dilution of biofilm. All those who use hyaluronic acid when treating their patients should have technical mastery of hyaluronidase application.
Keywords: HYALURONIC ACID; ENZYMES; ACCIDENTS.