Introduction:There are both unpublished and published anecdotal case reports of skin rash, acneiform eruptions and onset of Herpes simplex in patients injected with botulinum toxin for treatment of facial wrinkles and hyperhidrosis. We carried out a research to determine if there are immunological changes in the skin in ab initio treatment of patients with botulinum toxin. Methods: The immunological response to botulinum toxin type A was assessed in skin before and after its application in 15 patients with axillary hyperhidrosis. The following immunohistochemical markers were used to determine the local immunological profi le before and after application of botulinum toxin: CD4+, CD8+, CD1a, CD25, anti-TNF-á, HLA-Dr, ICAM-1, anti- IFN-ã and anti-IL-4. Results and discussion: A descriptive statistical analysis of each marker was carried out and the data were analyzed by Wilcoxon sign test. It was concluded that there was no alteration in skin after hyperhidrosis treatment with botulinum toxin a when markers were compared.

Keywords: AXILLARY, HYPERHIDROSIS, IMMUNOLOGICAL RESPONSE, BOTULINUM TOXINS, BOTULINUM TOXIN, HIPERHIDROSIS TREATMENT

Although treating contagious molluscum with 5% potassium hydroxide solution is common, some studies challenge its efficacy. Ten patients (aged 4-13) with a total of 141 lesions were evaluated. After 28 days of treatment there were 105 lesions (75% of the initial amount), none of which achieved total resolution. Persistent lesions were curetted in up to two sessions; 28 of the 105 lesions remained after treatment. The percentages of reduced or completely resolved lesions were higher for curettage than potassium hydroxide (71% x 9%, p = 0 .01 vs. 80% x 0%, p = 0.02).

Keywords: MOLLUSCUM CONTAGIOSUM, THERAPEUTICS, CURETTAGE

Primary cutaneous nodular amyloidosis is a rare form of amyloidosis. The authors report the case of a 44-year old woman with nodules and plaques on the legs with three years of development and increase in the number and size of lesions. Clinical, histological and laboratory investigation dismissed the possibility of systemic amyloidosis, and the diagnosis of nodular amyloidosis was established. A decision was made for the surgical approach, using curettage and cauterization with good response to the proposed treatment.

Keywords: AMYLOIDOSIS; CURETTAGE; CAUTERY

Aspiration curettage of sweat glands is a minimally invasive surgical technique for the treatment of axillary hyperhidrosis. It is safe and easy to perform, offers a high success rate and comparatively few side effects. It is generally well tolerated by patients and requires a reduced recovery time when compared to other surgical modalities.

Keywords: HYPERHIDROSIS; SURGERY; CURETTAGE

O queratoacantoma (QA), apesar de frequente na prática diária, é um tumor que gera questionamentos. O aspecto mais intrigante associa-se à sua posição no limite entre malignidade e benignidade. A abordagem do tumor, bem como sua classificação, é controversa. Na definição da conduta, é importante levar em conta o potencial de transformação para carcinoma espinocelular. Desse modo, a excisão cirúrgica é a terapia de escolha, sempre que possível. Algumas situações merecem atenção adicional, como a imunossupressão associada. Neste artigo, relatamos um caso de QA gigante em um paciente com síndrome da imunodeficiência adquirida tratado com cirurgia micrográfica de Mohs.

Keywords: Ceratoacantoma; Retalhos Cirúrgicos; Neoplasias Nasais; Neoplasias Cutâneas; Cirurgia de Mohs; Síndrome de Imunodeficiência Adquirida; HIV; Imunossupressão