Introduction: Acne vulgaris is an inflammatory disorder that affects the pilocebaceous gland with high prevalence among young adults. Studies have suggested that FFA may influence acne vulgaris. However, the pathogenesis of acne is not yet fully known.
Objective: To analyze the correlation between free fatty acid and acne vulgaris severity level.
Methods: Forty-three female high school students with mild, moderate, and severe acne were included in this study. Free fatty acid level, represented by palmitic acid level, was measured using gas chromatography and PCR examination was conducted to detect Propionibacterium acnes. Mann-Whitney test was used to analyze the median palmitic level difference between groups with different acne vulgaris severity. A p-value <0.05 was considered as significant.
Results: Fourteen patients (32.6%) had mild acne vulgaris, while 14 and 15 patients had moderate and severe acne vulgaris, respectively. The severe and moderate acne group showed significantly higher palmitic acid level compared to the mild acne group (p<0.05). The level of palmitic acid was not associated with the presence of P. acnes.
Conclusions: Increased palmitic acid level was found to be associated with acne severity. Thus, FFA levels may be used as a marker to determine acne vulgaris severity

Keywords: Acne vulgaris; Fatty acids, nonesterified; Polymerase chain reaction; Propion-ibacterium acnes

INTRODUCTION: The proteins involved in the process of epidermal differentiation play a key role in retention of water and maintenance of the stratum corneum.
OBJECTIVE: To assess the compaction of the skin barrier and protein expression of filaggrin, involucrin, loricrin and sphingomyelin after the use of a moisturizing cream containing saccharide isomerate and hydroxyethyl urea.
MATERIALS AND METHODS: Ex vivo evaluations were performed in skin culture in addition to immunofluorescence in order to identify proteins, as well as in vitro analysis with tissue culture in culture medium and histological sections, all of which compared with a control group.
RESULTS: In the ex vivo evaluation, the protein markers increased in the group treated with the moisturizing cream as compared to the skin culture model with atopic dermatitis. In the in vitro evaluation, it was possible to observe an improvement in the skin barrier compaction with the application of the cream on a reconstituted three-dimensional epidermis model, as compared with the control.
CONCLUSIONS: The moisturizing cream promoted a significant increase in the production of filaggrin, involucrin and loricrin, as well as in the compaction of the skin barrier, thus suggesting a positive effect on skin hydration and protection of the cutaneous barrier, preserving and restoring the skin.

Keywords: Administration; Amino acids; Carbohydrates; Cutaneous; Fluid therapy; Keratins; Keratinocytes; Skin; Skin care; Skin cream; Peptides; Proteins; Urea; Wetting agents

O queratoacantoma (QA), apesar de frequente na prática diária, é um tumor que gera questionamentos. O aspecto mais intrigante associa-se à sua posição no limite entre malignidade e benignidade. A abordagem do tumor, bem como sua classificação, é controversa. Na definição da conduta, é importante levar em conta o potencial de transformação para carcinoma espinocelular. Desse modo, a excisão cirúrgica é a terapia de escolha, sempre que possível. Algumas situações merecem atenção adicional, como a imunossupressão associada. Neste artigo, relatamos um caso de QA gigante em um paciente com síndrome da imunodeficiência adquirida tratado com cirurgia micrográfica de Mohs.

Keywords: Ceratoacantoma; Retalhos Cirúrgicos; Neoplasias Nasais; Neoplasias Cutâneas; Cirurgia de Mohs; Síndrome de Imunodeficiência Adquirida; HIV; Imunossupressão

Sarcomas são neoplasias mesenquimais malignas, raras, que acometem, principalmente, crianças e adolescentes. O rabdomiossarcoma, subtipo oriundo da musculatura esquelética, é condição incomum em adultos, acometendo sítios de localização não habitual, crescimento rápido e de difícil tratamento. Apresenta-se caso de adulto jovem com nodulação em lóbulo auricular esquerdo, cuja análise histopatológica e imuno-histoquímica confirmou tratar-se de rabdomiossarcoma alveolar, o qual foi conduzido em conjunto com a Oncologia.

Keywords: Rabdomiossarcoma Alveolar; Miogenina; Desmina; Excisão de Linfonodo