Amyloidosis is characterized by the deposition of a modified protein. It can affect the skin by accumulating in the papillary dermis. In general, it develops with brownish maculae predominant in the interscapular region, and rarely coursing with generalized forms. This report describes a 59 year-old female patient who had had a spot in the lower back for 43 years, which in the last 8 years had progressively spread for the entire body. Dermoscopy has proven extremely effective in locating the various foci of pigmentary incontinence, which together with apoptotic keratinocytes constitute the pathophysiological basis for the formation of the amyloid protein.

Keywords: AMYLOIDOSIS; CONGO RED; DERMOSCOPY

Although primary cutaneous amyloidosis (PCA) is prevalent worldwide, it is underdiagnosed. Among the subtypes, nodular amyloidosis (NA) is the rarest. There is no consensus in the literature; treatment is challenging, and no therapy has been proven effective. The authors report the case of a patient with a nodule in the nose, whose anatomopathological examination was compatible with amyloidosis, with no evidence of systemic disease. It was then classified as nodular PCA. The lesion was excised satisfactorily. It was concluded that surgical removal is an effective therapy for the treatment of NA.

Keywords: Amyloidosis; Amyloid; Congo Red