Introduction: Several therapeutic modalities have been used to treat keloids and hypertrophic scars. Objective: Treatment of keloids and hypertrophic scars with excision and intralesional injection of methotrexate. Methods: Therapeutic intervention open study with 11 patients. Laboratory tests and photographs were carried out before, during, and after the treatment. From the seventh day after the excision of the lesions, the suture was injected weekly with methotrexate for six months. The weekly dose was 2.5 mg / 10cm suture, with a maximum dose of 5mg per patient. The evaluation was carried out by the physician and the patient. Results: Six months after the end of the treatment, there was no recurrence of the lesion in five cases, partial recurrence in six cases and an absence of cases with total recurrence. No alterations were observed in the laboratory tests. Conclusions: The maximum weekly dose of 5mg methotrexate for six months used in this pilot study to treat keloids and hypertrophic scars is safe and hinders recurrence. Further studies are needed to complement the present paper.

Keywords: KELOID; CICATRIX, HYPERTROPHIC; THERAPEUTICS; SKIN.

Introduction: Melasma appears as a hyperpigmentation, which mainly affects body areas exposed to the sun, and is considered a common condition. Objective:To evaluate the efficacy of 82% lactic acid peeling in the treatment of facial melasma through a prospective and comparative study. Methods: Three fortnightly application sessions with 82% lactic acid peeling were carried out in 16 patients with facial melasma - eight of them were using the standard triple combination drugs for the treatment of hyperpigmentation while the others were untreated for 60 days. The Wilcoxon signed-rank test was applied in order to compare the two groups' values for the Melasma Area Severity Index. Results: The lactic acid peeling improved the hyperpigmentation in all patients studied, with no permanent side effects, proving to be an effective treatment. The Wilcoxon signed-rank test showed a significant reduction (p = 0.0003) in the Melasma Area Severity Index, in all patients. Conclusion: The 82% lactic acid peeling treatment can be an important tool in the improvement of resistant melasma.

Keywords: CHEMEXFOLIATION; THERAPEUTICS; SKIN; LACTIC ACID; HYPERPIGMENTATION.