Introduction:The French cosmetics industry sells spring mineral waters that are advertised as having biological benefits.
Objective: This study analyzes, in vitro and in vivo, a Brazilian mineral water''''''''s oligomin- erals composition, as well as its physical and chemical characteristics and biological effects.
Methods: Tests to evaluate physical chemical properties, cytotoxicity (viable cells) and irritability (het-cam test) were conducted. In vitro studies were performed to evaluate its capacity to induce the genic expression and immunohistochemical detection of filaggrin and aquaporin 3, nf-kb activity and fibroblast proliferation compared to Milli Q water.
Results: This water was found to be non-cytotoxic and non-irritating. In addition, it pre- sented a high content of strontium (0.61 mg/ml). The expression of filaggrin and its immunohistochemical tests were relevant. The aquaporin 3 increased 1.8 times and nf-kb decreased its activity by 47%. It was also capable of stimulating fibroblast proliferation.
Conclusion: The initial evaluation of the mineral water from Serra do Japi (SP, Brazil) indicates that it has the potential to be an adjuvant treatment in dermatology, since the results suggest it moisturizes the skin barrier, stimulates the proliferation of fibroblasts, and repairs and inhibits inflammatory reactions. Clinical studies should be done in order to reassure the in vitro results achieved on the present study.

Keywords: MINERAL WATERS, BRAZIL, COSMETICS

Introduction: Introduction: Mineral water has been used in Dermatology for its moisturizing and anti-inflammatory effects. Its penetration seems to be superficial. An elastic liposome containing mineral water was developed in efforts to improve its penetration and action in the skin.
Objectives: This study evaluated the efficacy of a 30-100 nm liposome, made of trehalose and soy phosphatidylcholine, which can cross 30 nm spaces and deliver the mineral water to deeper layers of the skin.
Methods: The RAMAN method was used to evaluate the permeation of the liposome into the skin. Its moisturizing effects were measured through the genic expression of filaggrin and acquaporin, and its anti-inflammatory effects were measured through NF-¿ß quantities.
Results: After 30 minutes, the phosphatidylcholine was localized 1-7 nm deeper in the corneum layer; 60 minutes after, the liposome had penetrated to the spinous layer; and no changes were verified after 120 minutes. The genic expression of filaggrin increased 3 times and the expression of acquaporin increased 1.8 times. NF-¿ß activity decreased 47%.
Conclusion: Nanotechnology and its benefits are very important to dermatology. The development of liposomes with Brazilian technology demonstrates the emergence of a knowledge base regarding cosmetic delivery systems in the country. Therefore, Brazil''''''''s wealth of mineral spring waters represents a considerably valuable resource and should be the object of further studies in dermatology. This study has verified that liposome-encapsulated water can permeate the skin and provide enhanced biological effects.

Keywords: MINERAL WATERS, LIPOSOMES, SKIN, COSMETICS, AMBULATORY SURGICAL PROCEDURES, SURGICAL PROCEDURES, MINOR

The French cosmetics industry has been marketing thermal mineral waters that have certain biological effects. Previous studies have demonstrated that oligomineral elements have hydrating, antioxidant, and anti-inflammatory properties. This literature review discusses in vitro and in vivo clinical studies of commercially available thermal mineral waters to determine their effects on the skin and their main indications. A historical review was also carried out on the use of thermal mineral waters in dermatology, with an emphasis on identifying their physical and chemical properties and comparing the qualitative composition of the oligominerals present in those waters.

Keywords: MINERAL WATERS, SKIN, COSMETICS, HYDROTHERAPY

INTRODUCTION: The proteins involved in the process of epidermal differentiation play a key role in retention of water and maintenance of the stratum corneum.
OBJECTIVE: To assess the compaction of the skin barrier and protein expression of filaggrin, involucrin, loricrin and sphingomyelin after the use of a moisturizing cream containing saccharide isomerate and hydroxyethyl urea.
MATERIALS AND METHODS: Ex vivo evaluations were performed in skin culture in addition to immunofluorescence in order to identify proteins, as well as in vitro analysis with tissue culture in culture medium and histological sections, all of which compared with a control group.
RESULTS: In the ex vivo evaluation, the protein markers increased in the group treated with the moisturizing cream as compared to the skin culture model with atopic dermatitis. In the in vitro evaluation, it was possible to observe an improvement in the skin barrier compaction with the application of the cream on a reconstituted three-dimensional epidermis model, as compared with the control.
CONCLUSIONS: The moisturizing cream promoted a significant increase in the production of filaggrin, involucrin and loricrin, as well as in the compaction of the skin barrier, thus suggesting a positive effect on skin hydration and protection of the cutaneous barrier, preserving and restoring the skin.

Keywords: Administration; Amino acids; Carbohydrates; Cutaneous; Fluid therapy; Keratins; Keratinocytes; Skin; Skin care; Skin cream; Peptides; Proteins; Urea; Wetting agents

INTRODUCTION: The term inflammaging refers to the increase of the inflammatory response due to aging, resulting in a low level chronic pro-inflammatory state. High levels of proinflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor occur. Thus, the use of active principles that modulate the inflammatory response assists in the reduction of cellular oxidative stress, also reducing or avoiding irreversible cellular and non-clinically detectable molecular damage.
OBJECTIVE: To evaluate the action of a compound containing collagen peptides, Delphinol^®, vitamin C and hibiscus on the modulation of the cutaneous inflammatory response.
SUPORTE FINANCEIRO: Laboratório Farmoquímica, Rio de Janeiro - RJ, Brasil. Conflito de Interesses: Os autores afirmam não possuir interesses pessoais, comerciais, políticos ou financeiros neste manuscrito.
MATERIALS AND METHODS: The release of inflammatory cytokines after treatment with the product was evaluated in keratinocytes exposed to an inflammatory response-inducing lipopolysaccharide.
RESULTS: When keratinocytes were exposed to the studied compound, it was possible to observe an increase in the release of interleukin 6 and a reduction tendency in the levels of interleukin 1-alpha and interleukin-8. In addition, the release of basal tumor necrosis factor-alpha was reduced by 67.5% (P = 0.008).
CONCLUSIONS: The compound studied has a potential effect on inflammaging — and consequently on aging — by modulating the inflammatory cytokines interleukin-1 alpha, interleukin-6, interleukin-8 and tumor necrosis factor-alpha.

Keywords: Aging; Anti-Inflammatory agents; Antioxidants; Ascorbic acid; Collagen; Dietary Suplements; Hibiscus; Inflammation mediators; Skin; Skin aging