Introduction: Melasma is a highly prevalent dermatosis that greatly affects patients'''''''' quality of life and is challenging to treat.The Melasma Area and Severity Index and the Melasma Quality of Life Scale are useful tools in the clinical and impact on quality of life evaluations, respectively. Objective: To compare the effects of 5% and 10% retinoic acid peels in patients with melasma, using the Melasma Area and Severity Index and the Melasma Quality of Life Scale to evaluate the clinical and quality of life impacts, respectively . Methods: Patients (n = 30) were randomized to receive either 5% or 10% retinoic acid peels in weeks 0, 2, 4 and 6 of the treatment. Clinical and quality of life evaluations took place in weeks 0 and 8. Results: In a global evaluation of the two groups, there was a statistically significant improvement in scores from baseline to week 8, yet there were no statistically significant differences between treatment groups. Conclusions: Retinoic acid peels are effective and safe, as an isolated therapy, in the treatment of melasma.There is no difference in treatment results between 5% and 10% concentrations.

Keywords: MELANOSIS, TRETINOIN, THERAPEUTICS, QUALITY OF LIFE

Dermatofibrosarcoma protuberans is a spindle cell neoplasm of intermediate malignancy, nonetheless it presents a high risk of local recurrence. It mainly affects the trunk and limbs, and is rare on the face. The treatment of the tumor can be carried out using conventional surgery with wide surgical margins or Mohs micrographic surgery. Radiation and chemotherapy can be indicated in selected cases. The present article reports the case of a 39-year-old male patient with a 0.7cm yellowish papule on the forehead, whose biopsy and immunohistochemistry confirmed the tumor's diagnosis. The lesion was treated through Mohs micrographic surgery with good aesthetic results.

Keywords: DERMATOFIBROSARCOMA; SARCOMA; MOHS SURGERY

Dermatofibrosarcoma protuberans is a locally aggressive sarcoma of intermediate malignancy that predominates in the range of young adults to middle age. Congenital or childhood lesions are rare but have been reported. It can be misdiagnosed and incompletely excised in the early stages, which increases the risk of recurrence. The present article reports the case of a 24-year-old male patient presenting a hyperchromic macula in the abdominal region from birth that evolved into a tumor after several surgical approaches. Biopsy and immunohistochemistry confirmed the diagnosis of dermatofibrosarcoma protuberans, and the lesion was excised with a 3 cm margin.

Keywords: Dermatofibrosarcoma; Neoplasms, Fibrous Tissue; Sarcoma