Introduction: Melasma is a common acquired hypermelanosis of difficult treatment due to the fact that it is a refractory and recurrent condition. Pycnogenol is a powerful antioxidant that can be effective in the treatment of melasma owing to its protective action against ultraviolet radiation. Objectives: To evaluate the effectiveness of 100 mg/day pycnogenol in the treatment of melasma. Methods: Prospective, randomized, interventional study carried out with 31 patients. The selected participants made use of 100 mg / day pycnogenol and sunscreen for 90 days. They were evaluated regarding the extent of melasma (MASI) and quality of life (MELASQol). Results: Efficacy results showed a significant reduction (p <0.05) in the scores for both scales (MASI and MELASQol). According to the participants' self-evaluation, 94.4% of them showed clinical improvement. Conclusion: 50 mg pycnogenol was shown to be effective in the treatment of melasma after use of 2 tablets / day for 90 days. The results for the MASI and MELASQoL (Melasma Quality of Life Scale) scores were statistically significant. Furthermore, the product was proven to be safe due to the low incidence of side effects.

Keywords: MELANOSIS; CHEMOPREVENTION; ADJUVANTS, PHARMACEUTIC

Introduction: The application of botulinum toxin in the perioral region is a minimally invasive procedure that leads to substantial improvement in the signs of aging in addition to increasing the volume of the lips. However literature on this procedure is still scarce.
Objective: To evaluate changes in shape and volume of the lips, as well as the patients' satisfaction after the application of botulinum toxin in perioral lines.
Methods: Nineteen patients underwent evaluation, photographic record and measurements following the application of botulinum toxin in the perioral region, being subsequently assessed for changes in the lips and satisfaction.
Results: Most of the patients rated their lips as moderately or significantly more attractive after the application of botulinum toxin (p = 0.039). Fifteen women deemed the changes in the lips as a major factor in the overall improvement of their faces.
Conclusions: The use of botulinum toxin in the perioral region leads to the elevation of the upper lip, causing the shortening of the philtrum and the extension of the vermilion. The application of botulinum toxin in the vermilion's border leads to the relaxation of the orbicularis muscle, favoring a more intense tonus effect arising from the upper lip lifting muscles. The patients' satisfaction with the appearance of their lips was evaluated by four additional questions (linked to the lip's shape, volume, attraction and beauty), receiving positive answers. Side effects were minimal.

Keywords: LIP; BOTULINUM TOXINS, TYPE A; BOTULINUM TOXINS