INTRODUCTION: Photoaging results from the action of external agents, the main being ultraviolet radiation. It is clinically characterized by yellowish skin with irregular pigmentation, presence of wrinkles, atrophy, telangiectasias, decreased elasticity, and premalignant and malignant lesions. It corresponds to one of the most common dermatological complaints, requiring that dermatologist physicians keep up-to-date regarding treatments.
OBJECTIVE: To evaluate the effect of imiquimod in the treatment of photoaging.
METHODS: A prospective intervention study was carried out involving 12 female patients. The response was clinically assessed by the patient and examiner physician, and in light of histological parameters.
RESULTS: Six of the 12 patients, experienced side effects – three of which dropped out of the study. Of the 9 patients who completed the treatment, 8 perceived an overall improvement in the appearance of the skin. The examiner physician could observe improvement in 8 patients – slight in 6, and significant in 2 of them. Regarding histological aspects, there were decreases in solar elastosis (4 patients), melanin amount (5 patients) and fibrosis (4 patients).
CONCLUSIONS: Imiquimod can be an option for the treatment of photoaging, and should be evaluated in subsequent, controlled studies with larger samples.

Keywords: Skin; Skin aging; Administration, Topical

The cuniculatum carcinoma is a rare, slow-growth, local aggressive subtype of the squamous cell carcinoma, presented as a verrucous lesion with a low metastasis capacity. Its histopathology shows keratin-filled crypts, and its etiology is linked with HPV, especially 11 and 16 subtypes. The treatment of choice is surgical excision, followed by regular monitoring due to the high risk of local recurrence. We report a case of a woman with Cuniculatum carcinoma treated with surgery with perioperative frozen section procedure, graft, and good evolution.

Keywords: Carcinoma; Carcinoma, Squamous Cell; Foot