Introduction: Hyperhidrosis is the cause of intense suffering and embarrassment. Currently there are many treatments available for this disorder, however none of them offers guaranteed and lasting effectiveness. Objective: To evaluate the effectiveness of bipolar radiofrequency in axillary hyperhidrosis. Methods: Five patients were selected using the Minor positive test with clinical, photographic, and histological evaluations before and after the procedure. Six weekly sessions were carried out. Results: The patients rated the improvement as satisfactory, with some considering it almost complete. The photographic assessment showed negative for the Minor test and the biopsy did not evidence dermal fibrosis. Conclusion: Bipolar radiofrequency can be considered a safe method, with low complication rates and an excellent additional option in the treatment of hyperhidrosis.

Keywords: HYPERHIDROSIS; SWEATING; LASER THERAPY; AMBULATORY SURGICAL PROCEDURES

Pyogenic granuloma or lobular capillary hemangioma is a benign skin and mucous membranes lesion whose etiology is not yet explained. The authors report an atypical and exuberant clinical case of this benign dermatologic condition, clinically simulating malignancy.

Keywords: GRANULOMA, PYOGENIC; SCALP DERMATOSES; HEMANGIOMA, CAPILLARY; MELANOMA

Introduction: Stromal vascular fraction derived from adipose tissue is a rich source of different cells, containing large amounts of stem cells, which ability for diferentiation into various strains. In dermatology, there are several studies on the effectiveness of stem cells, which present antioxidant and rejuvenating effects. However, there are few reports about the anti-aging effects of stromal vascular fraction.
Objective: To evaluate the effectiveness of stromal vascular fraction in facial rejuvenation.
Methods: A prospective, comparative, controlled study was carried out, wit, with 10 patients divided into two groups and subjected to treatment of nasolabial folds with: Group 1: stromal vascular fraction and Group 2: conventional filler (calcium hydroxyapatite). Clinical, photographic and histological evaluations were conducted, with statistical analysis of data.
Results: Both techniques produced satisfactory results and were similar.
Conclusion: Application of stromal vascular fraction is a relatively new technique that presents good clinical results and is a promising option for rejuvenation.

Keywords: ADULT STEM CELLS; SKIN AGING; REJUVENATION

Systemic oral medications – such as cyclosporine (CYA) or methotrexate (MTX) – for the treatment of psoriasis have limited bioavailability due to incomplete gastrointestinal absorption and first-pass hepatic metabolism. Moreover, they are associated with adverse effects. The application of CYA or MTX using the microinfusion of drugs into the skin method (MMP^®) for the treatment of psoriasis vulgaris yielded a therapeutic response with significant reduction of lesions, and absence of side effects. In the present report, the authors describe 4 cases of psoriasis vulgaris treated using the MMP^® method, with the application of CYA or MTX.

Keywords: Cyclosporine; Methotrexate; Psoriasis

INTRODUCTION: During aging, the skin undergoes structural, cellular, and molecular changes that alter its mechanical properties as well as its biological and physiological functions.These changes manifest as loss of elasticity, and turgor, with consequent appearance of fine wrinkles, lines, and creases that are difficult to resolve, being considered a therapeutic challenge.
OBJECTIVE: To describe the technique of applying cohesive polydensified matrix hyaluronic acid for the treatment of superficial wrinkles.
MATERIALS AND METHODS: In this retrospective and observational study, the technique of superficial and transverse application to superficial wrinkles with cohesive polydensified matrix hyaluronic acid was performed in women with this type of wrinkles in the perioral, periorbicular and lateral regions of the face, which did not disappear after treatment with botulinum toxin, facial volumization with fillers and technology.The study was conducted over 22 months between 2016 and 2018.The degree of improvement was assessed by a questionnaire applied to the patients who observed paired standardized photographs taken in the previous period and one month after the treatment.
RESULTS: The technique was performed on 40 women aged 55 to 80 years, whose response to the evaluation questionnaire was improved between 90% and 100% after one month of treatment.
CONCLUSIONS: The technique of superficial and transverse application to wrinkles with cohesive polydensified matrix hyaluronic acid proved to be an excellent option for the treatment of affected areas, without significant adverse events and/or Tyndall effect, with a high degree of patient satisfaction.

Keywords: Hyaluronic acid; Skin aging; Skin care

In the skin aging process, both intrinsic alterations, secondary to cell regeneration capacity loss resulting from chronological action, and extrinsic alterations, caused by to ultraviolet radiation exposure, can be observed. Treatments that restore collagen production and stimulate fibroblasts to synthesize and organize extracellular matrix are critical for morphogenesis, angiogenesis, and skin healing. Potential uses of products that stimulate collagen production, a component that plays a fundamental role in the extracellular matrix, represents a promising perspective for improving skin quality and its mechanical properties by introducing a new concept of therapeutic approach when treating changes caused by skin aging.

Keywords: Collagen; Hydroxyapatite; Skin Aging

Microinfusion of drugs into the skin (MMP^®) is a technique described by Arbache in 2013. It uses a tattoo machine to infuse drugs to treat skin diseases. This study aims to review the literature and list the indications already published on this technique, the medications used in the procedure, and this technique’s safety profile. Despite being widespread among dermatologists, microinfusion of drugs into the skin (MMP^®) requires careful analysis, as many indications lack scientific literature. Even though it is a promising technique, it needs further studies to consolidate its indications and assess its safety profile.

Keywords: Infusions, Intralesional; Research and New Techniques; Tattooing