Introduction: Melasma is a pigmentation disorder that mainly affects women of childbearing age with high phototypes. Polypodium leucotomos has antioxidant, photoprotective and immuno-modulatory activity, and can be considered as an adjunctive treatment for melasma.
Objective: To evaluate the efficacy, in relation to quality of life and objective improvement, of the use of Polypodium leucotomos in the treatment of melasma.
Methods: Prospective and individualized study. Nine volunteers with melasma were submitted to treatment with Polypodium leucotomos for 45 days. MELASQoL, DLQI and MASI scores were calculated at the beginning (D0) and 45 days after (D45). Analysis of variance ANOVA with Tukey post-test for comparison be-tween D0 and D45 (p <0.05).
Results: All patients were females, mean age of 37.18 ± 6.78 years. Family history of melasma in 55.6%; 88.9% with unprotected photoexposure and use of estrogen. After 45 days of treatment with Polypodium leucotomos there was a significant reduction of ME-LASQoL and DLQI (p <0.05) and improvement of MASI in 55.6% of the patients.
Conclusions: There was improvement of MASI in 55.6% of patients after 45 days of treatment. In spite of the slight improvement in MASI, there was a reflex in the improvement of quality of life scores (DLQI and MELASQoL).

Keywords: MELANOSIS; POLYPODIUM; QUALITY OF LIFE; INDICATORS OF QUALITY OF LIFE

INTRODUCTION: Vitiligo is an acquired skin dyschromia characterized by the physical and/or functional reduction of melanocytes. We present two surgical proposals for the treatment of vitiligo.
CASE REPORTS: 1) Implant of skin graft diluted in hyaluronic acid gel: We obtained the material through curettage, diluted it in hyaluronic acid gel, and applied it to receptor areas. 2) Epidermal suspension obtained through curettage and diluted in hyaluronic acid gel: After the curettage of the donor area, we treated the material with trypsin-EDTA, centrifuged it, and diluted it in hyaluronic acid gel. The receptor area received the graft.
CONCLUSION: These are safe, easy, and satisfactory surgical procedures for the presented cases.

Keywords: Vitiligo; Keratinocytes; Ambulatory surgical procedures

BACKGROUND: Sentinel Lymph Node (SLN) status has been shown to be the strongest independent prognostic factor of cutaneous melanoma (CM) stage I-II patients. Few papers on CM at private clinics (PC) are available.
OBJECTIVE: To present clinical and histologic data, complications and frequency of SLN involvement in CM patients diagnosed and followed at a dermatology/cutaneous oncology PC in São Paulo/Brazil, who were submitted to SLNB.
METHODS: Retrospective, single-center cohort of patients who attended PC from June 1998 to Jan 2020. Electronic files were selected and analyzed. Minimum period for considering the patient eligible was 1 year.
RESULTS: 215 CM lesions were identified in 184 patients(1.2 melanoma/patient). Forty-seven patients (25.5%) were submitted to SLNB and 59 SLN for histologic examination (1.2 SLN/patient). 10,9% tested positive. SLN identification happened in 95.7%. In 38/47 (80,8%) patients single LBD was found, while multiple-LBD was found in 9/47(19.1%). Eighteen(72,0%) out of 25 trunk lesions drained to single basin, while in 7 patients multiple LBD was found. Complication rate was 6,0%.
CONCLUSION: Percentage of CM patients that undergo SLNB, node positivity for metastasis, draining basins and complications in this study were similar to studies in northern hemisphere patients. Clinical and epidemiologic characteristics of CM patients differ markedly between PC and PHS patients.

Keywords: Biopsy; Melanoma; Sentinel lymph node