Introduction: The skin is the largest organ of the human body and constitutes a covering layer that has many essential functions such as defense, sensorial, thermoregulatory, and aesthetic. Therefore, maintaining its integrity is extremely important for the homeostasis of the organism. Objective: To evaluate the efficacy and safety of a cutaneous moisturizer that, in addition to traditional substances, contains in its composition other ingredients capable of stimulating the function of the aquaporins. Methods: One hundred volunteers were clinically evaluated through medical examination and subjective self-evaluation, regarding the efficacy and safety of the product. Of these, 30 also underwent instrumental analysis through corneometry (assessment of the skin's hydration), pH metry (measurement of the skin's pH) and TEWLmetry (assessment of TransEpidermal Water Loss). Results: During a 90-day study, all efficacy variables subjectively analyzed showed clinical improvement (dryness, hydration, softness, desquamation, and itching). In the analysis of objective variables, it was observed that the corneometry measurements showed a significant increase in skin hydration. Conclusion: With the present study's clinical outcomes, the test product was proven effective for having significantly increased skin hydration (according to corneometry) and extremely efficient for its action on the signs and symptoms of skin xerosis (according to theassessment of the physiciansand volunteers).

Keywords: HYDRATION, DESICCATION, AQUAPORINS.

Basal cell carcinoma corresponds to the majority of malignant cutaneous malignancies in Brazil, predominating in middle-aged white individuals, mainly affecting the upper two-thirds of the face and occurring due to several etiological factors. The ideal treatment consists of complete removal with free lesion margins. For better functional and aesthetic results, reconstruction of the surgical wound with flaps or grafts may be necessary. Two types of reconstruction are described in patients with double surgical defects on the face, close to each other: one with a single rotation flap and another with a double rotation flap, also called Yin-Yang.

Keywords: SKIN NEOPLASMS; CARCINOMA, BASAL CELL; SURGICAL FLAPS