Surg Cosmet Dermatol. 2015;7(2):123-128
Introduction: The skin may present dysfunctions that result in histological alterations and elementary lesions, many of them caused by immunologic mechanisms and/or alterations in the epidermal barrier.
Objective: The present study was aimed at verifying in vitro whether some cosmetic products marketed in Brazil in the form of liquid soaps, have anti-inflammatory and protective efficacy in the skin barrier.
Methods: An in vitro study was carried out with four commercial soaps, which were evaluated in a cell culture of human keratinocytes for the determination of their anti-inflammatory and epidermal barrier restorative effects, as well as their capacity to reduce cutaneous hypersensitivity. Concentrations of keratin 10 and 14, loricrin, IL-12, IFN-γ and TRP V-1 were measured in the cell culture supernatants of human keratinocyte through the sandwich ELISA assay.
Results: The four test substances led to significant reductions in the synthesis of IFN-γ and IL-12. Only the test substance C triggered a significant increase in the synthesis of keratin 10. All test substances showed significant reductions in the synthesis of keratin 14 and TRPV-1, and a significant increase in the synthesis of loricrin.
Conclusions: Some cosmetic products in the form of soap can have in vitro results regarding their anti-inflammatory, epidermal barrier restoration and skin hypersensitivity reduction effects.
Keywords: ANTI-INFLAMMATORY AGENTS/ADVERSE EFFECTS; DERMATITIS, ATOPIC; SOAPS