Introduction: Intradermotherapy with poly-revitalization is an additional therapeutic option for the treatment of photodamage. Objective: To evaluate the efficacy of intradermotherapy treatment and skin rejuvenation results due to the use of injectable poly-revitalizing substance constituted of antioxidants, vitamin complexes, amino acids, coenzymes, and hyaluronic acid without crosslinking. Method: A retrospective, monocentric, open and non-comparative clinical study with 30 female patients who underwent 5 applications of injectable poly-revitalizing substance in the face. The photographs were analyzed and compared by blinded investigators and the medical professional who applied the treatment. Dermal thickness and density were analyzed and compared through ultrasonography. Result: Increased dermal thickness and density verified through ultrasonography. Clinical improvement was observed through pre- and post-application photographs. Conclusion: Intradermotherapy with the studied poly-revitalizing substance was proven to be a good therapeutic option for the treatment of photodamage.

Keywords: SKIN AGING; MESOTHERAPY; ULTRASONOGRAPHY.

Pilomatricoma is a benign skin tumor derived from the hair follicle. It has a varied etiology, and the traumatic one is often described as a triggering factor. The surgical treatment is curative and, therefore, the choice. We report a case of an atypical clinical presentation pilomatricoma – an ulcerated nodule topped by a central hematic crust, with peripheral telangiectasias probably triggered by the HPV vaccination. The ultrasound examination suggested the possibility of a chronic inflammatory granuloma, although the histopathological examination was definitive and confirmed the diagnosis of pilomatricoma.

Keywords: Papillomavirus vaccines; Hair follicle; Ultrasonography, Doppler; Skin neoplasms