A present a clinical case of a rare variant of dermatofibroma (aneurysmatic type), is presented in a 72-year-old female patient, the lesion was located in the right arm’s flexural fold, resulting from mesenchymal proliferation associated with blood vessels and tissular hemorrhage, with its own well defined histological characteristics. The objectives are to describe the rarity of the lesion and its histopathologic importance, when compared to other benign and malignant tumors in the differential diagnosis, in addition to the terminology currently used.

Keywords: BENIGN FIBROUS HISTIOCYTOMA, MALIGNANT FIBROUS HISTIOCYTOMA, HEMOSIDERIN

INTRODUCTION: Sclerotherapy is the most widely used method for the treatment of varicose veins of the lower limbs. The most common complication is the appearance of hyperchromic spots in the treated region. Pycnogenol^® has long been known as a phlebotonic, anti-inflammatory and skin depigmenting drug. Studies have already proven the efficacy of this drug in the prevention and treatment of post inflammatory hyperpigmentation.
OBJECTIVE: To evaluate the effectiveness of Pinus pinaster extract (Pycnogenol^®; PPE) in the prevention of hemosiderin deposits in human skin culture submitted to inflammatory stress.
METHODS: Fragments of human skin were stimulated with interleukin 1 alpha (IL-1 α) to induce an inflammatory response and, concurrently treated with PPE for further histological evaluation and hemosiderin semi-quantification.
RESULTS: The histological evaluation of skin fragments exposed to IL-1 alpha revealed a 26.6% higher hemosiderin density compared with the control group. Moreover, skin fragments incubated concomitantly with PPE showed significant reductions in hemosiderin deposits when compared with the group only exposed to the inflammatory microenvironment.
CONCLUSIONS: The results presented in this study showed an important effect of PPE (Pycnogenol^®) in the prevention of hemosiderin accumulation caused by inflammatory stress similar to the post-sclerotherapy process.

Keywords: Hemosiderin; Hyperpigmentation; Sclerotherapy

Atrophic acne scars result from an abnormal wound-healing response that can be treated with microneedling (MN). Insulin may play a role in wound healing. The effectiveness and safety of combining MN with topical insulin as an alternative therapy for atrophic acne scar revision have not yet been widely reported. We report the case of a 33-year-old woman with an atrophic acne scar on the middle third of her face. The patient was treated with MN and topical insulin for four sessions at two-week intervals. MN plus insulin can be considered an alternative for acne scar revision.

Keywords: Acne Vulgar; Insulina; Cicatriz; Hiperpigmentação