Introduction: The skin is subject to intrinsic and extrinsic aging processes, which makes treating cutaneous photoaging clinically challenging.
Objective: To use objective and subjective parameters to evaluate the safety, tolerability, and clinical efficacy of a cosmetic product containing 0.05% retinaldehyde, 4% nicotinamide, and 1% Vitis vinifera extract in the treatment of skin aging.
Methods: A monocentric, prospective, open study evaluated 40 female volunteers (25-40 years old) with Fitzpatrick skin types I to IV, who used the dermocosmetic product for 60 consecutive days. Subjective assessments were carried out by the physician and the volunteer patients. In addition, ultrasound examination and objective assessment of photographic records using the Visia® imaging system, skin biopsies, corneometry, pH metry, and sebumetry were conducted.
Results: Thirty-six volunteers completed the study. Subjective evaluations revealed improvements in wrinkles, fine lines, sagging, vitality, and overall appearance. Ultrasound and skin biopsies showed increased collagen (94.4% and 30.6%, respectively). Pictures from the Visia® device demonstrated a reduction in stains, wrinkles, and pores, and improvements in the skin''''''''s texture. Sebumetry revealed a decrease in the oiliness and the pH. Measurements taken with the corneometer remained constant.
Conclusions: This dermocosmetic product is effective and safe in the treatment of photoaging.

Keywords: RETINOIDS, RETINALDEHYDE, NIACINAMIDE, SKIN AGING

INTRODUCTION: Melasma is a highly common dermatosis that has numerous therapeutic alternatives but tends to be a therapeutic challenge due to its refractory and relapsing nature.
OBJECTIVE: Comparison between intense pulsed light with pulse-in-pulse mode (IPL-PIP) and retinoic acid peel (RAP) for melasma treatment.
METHODS: We conducted six bi-weekly IPL-PIP sessions in the left hemiface and three-monthly RAP sessions in the right hemiface.The Melasma Area and Severity Index (MASI) and MelasQol questionnaires were applied before and one month after the last treatment session.
RESULTS: We observed a reduction of approximately 33% in hemiface MASI with RAP and of 35% in hemiface with IPL-PIP, showing significant improvement of melasma with both methods.There was no statistically significant difference between the two groups. Both practices were well tolerated by patients, but RAP had more reports of adverse events than IPL-PIP.There was a substantial improvement in the quality of life of the patients with both therapeutic methods.
CONCLUSIONS: RAP and IPL-PIP are effective in treating melasma and improving patients' quality of life.There was no statistical difference between the methods concerning lesion clearance and quality of life of patients.

Keywords: Chemexfoliation; Light; Melanosis; Retinoids