INTRODUCTION: Lysine is one of the essential amino acids, with a role in the prophylaxis of recurrent orolabial herpes simplex that has been demonstrated in scientific studies. Facial resurfacing procedures with laser and other technologies can reactive herpes simplex.
OBJECTIVE: To evaluate the incidence of cases of orolabial herpes in patients submitted to treatments with fractional ablative and non-ablative lasers and robotic microneedling, under prophylactic l-lysine.
METHODS: A sample of 100 was selected to have prophylactic l-lysine for herpes simplex. A re-evaluation of all patients was conducted seven days after laser treatment. If herpes infection was detected, doses of oral antiviral similar to those used for herpes-zoster treatment would be prescribed, guided by the literature.
RESULTS: Only 2% of the sample demonstrated herpes simplex after the procedure with prophylactic l-lysine. Both patients underwent ablative fractional laser treatment and had past history of herpes simplex infection.
CONCLUSIONS: Besides the low cost, l-lysine is a natural product that proved to be safe and effective for the prophylaxis of herpes simplex in resurfacing procedures, with a similar or lower rate of viral activation to the use of antivirals.

Keywords: Herpes Simplex; Herpes Labialis; Lysine; Laser Therapy; Lasers

INTRODUCTION: The treatment of hypochromic scars is challenging, and the techniques used so far show unsatisfactory results. Bimatoprost, an analog of prostaglandin F2-alpha, has been used as a topical pigment agent, and its application as drug delivery can optimize its delivery to the dermis and potentiate pigmentation.
OBJECTIVE: To evaluate the safety and efficacy of Ablative Fractional Laser (AFL) treatment associated with bimatoprost 0.03% drug delivery in hypopigmented scars.
METHODS: The patients were submitted to the AFL, followed by the application of bimatoprost 0.03% in 4 sessions with biweekly intervals. Clinical evaluations and standardized photographs were performed. Patients’ satisfaction was assessed using a 5-question questionnaire.
RESULTS: All patients had clinical improvement in the treated areas. The degree of patient satisfaction agreed with the clinical evaluation and photographic records.
CONCLUSION: The application of AFL associated with bimatoprost 0.03% drug delivery can be a potentially effective and safe treatment for hypochromic scars.

Keywords: Lasers; Hypopigmentation; Laser Therapy