Cylindroma is a rare benign neoplasm of probable origin in the eccrine sweat glands and is characterized by papular and nodular, painless, slow-growing lesions, generally located on the head, neck and scalp. When multiple, they can be part of hereditary syndromes. The authors report the case of a patient with a solitary nodulation on the scalp, presenting pathological examination compatible with cylindroma. The lesion was excised, with satisfactory results and no recurrence.

Keywords: Sweat Gland Neoplasms; Skin Neoplasms; Deubiquitinating Enzyme CYLD.

Although primary cutaneous amyloidosis (PCA) is prevalent worldwide, it is underdiagnosed. Among the subtypes, nodular amyloidosis (NA) is the rarest. There is no consensus in the literature; treatment is challenging, and no therapy has been proven effective. The authors report the case of a patient with a nodule in the nose, whose anatomopathological examination was compatible with amyloidosis, with no evidence of systemic disease. It was then classified as nodular PCA. The lesion was excised satisfactorily. It was concluded that surgical removal is an effective therapy for the treatment of NA.

Keywords: Amyloidosis; Amyloid; Congo Red