Perianal Buschke-Lowenstein tumor: report of two cases treated with 25% podophyllin ointment

Buschke-Lowenstein tumor (BLT) is an extremely rare variant of condylomata acuminata that presents a benign biological behavior and histological characteristics despite being clinically presented by large lesions. Many therapeutic approaches are available, many of which rely on extensive and mutilating surgical procedures. We present two cases of patients with BLT treated with topical podophyllin whose therapeutic responses were extremely favorable in both cases.

Keywords: Podophyllin; Condylomata Acuminata; Carcinoma, Verrucous; Neoadjuvant Therapy