Introduction: Microneedling is a technique aiming at stimulating the production of collagen as well as serving as drug delivery. Copaiba oil has healing and anti-inflammatory effects that have already been demonstrated in several animal models.
Objective: To evaluate the effect of copaiba oil associated with microneedle removal on the skin of rats.
Methods: Thirty rats were distributed in six groups of five animals each, subsequently undergoing: isolated microneedling, microneedling associated to mineral oil, and microneedling associated with copaiba oil. Biopsies were carried out in all animals at 14 and 30 days after the procedure. The parameters evaluated were: presence of collagen, fibroblasts and vessels, according to the following ratings: absence (0), mild (1), moderated (2) or intense (3).
Results: There was a statistically significant difference between the groups regarding the production of collagen at 14 days (p = 0.0091) and 30 days (p = 0.0357); and fibroblasts at 30 days (p = 0.0357). the group that used microneedling and copaiba oil, presented, after 30 days, a greater production of collagen and fibroblasts.
Conclusions: Copaiba oil associated with microneedling was capable of stimulating a greater production of collagen and fibroblasts in the skin of rats.

Keywords: dermatology; plants, medicinal; wound healing; collagen

Introduction: Being healthy corresponds to a state of absolute well-being. Scars are examples of con- ditions that endanger patients’ emotional integrity, compromising their quality of life. Consequently, there are several therapeutic alternatives aimed at alleviating aesthetic disorders. Microneedling stimu- lates collagen production, improving the healing effect in the induced cutaneous injury.
Objective: to evaluate the effect of microneedling in the scars of surgically induced cutaneous wounds in rats.
Methods: Twenty-four male rats were distributed in five study groups. A surgically induced incision was inflicted on the animals’ dorsa in all study groups, with the healing processes being followed up until completion.The study groups GC-14 and GC-30 served as controls for the groups GCM-14 and GCM-30, respectively
Results: Reepithelialization and absence of granulation tissue were identified in 100% of the groups. Regarding the proportion of fibrosis, mean reductions of 19% and 4% were observed in GCM-14 and GCM-30, respectively. There was a stimulus to the production of type I and III collagen in the groups that underwent microneedling, with a greater amount of type I collagen in GCM-14 (62.1%) as compared to its control (37.8%).
Conclusions: Microneedling was effective in stimulating increased production of collagen fibers in 14 days, suggesting this treatment tends improve scars.

Keywords: Cicatrix; Collagen; Models, animal