Surg Cosmet Dermatol. 2026;18(3):1-8
Enlarged or ptotic submandibular glands (SmG) can negatively impact the mandibular angle and facial contour. Although botulinum toxin type A (BoNT-A) is well established as a treatment for parotid hypertrophy, its use for the treatment of SmG enlargement remains underexplored. A literature search was conducted in the PubMed, Cochrane, and LILACS databases, covering studies from November 1977 to November 2024. Seven studies met inclusion criteria, encompassing animal models, cadaveric studies, clinical trials, and case reports. Studies reporting SmG size found volumetric reduction following BoNT-A administration. Current evidence suggests BoNT-A injections into the SmG effectively reduce gland volume and may enhance facial contour.
Keywords: Submandibular Gland; Botulinum Toxins, Type A; Neck; Aging; Esthetics