Squamous cell carcinoma (SCC) has the second highest incidence rate among non-melanoma skin cancers. About 5% of cases progress to locally advanced and/or metastatic lesions, making the surgical approach often unfeasible. Based on this, we performed a literature review on the use of immunotherapy drugs to treat advanced SCC. The results showed that immunotherapy is a potential therapeutic strategy due to the antitumor activity promotion through the individual immune response, reducing the adverse events of surgeries, chemotherapy, and radiotherapy

Keywords: Squamous cell carcinoma; Tumor Evasion; Immunotherapy; Skin neoplasms

INTRODUCTION: Temporal triangular alopecia (TTA) is a nonscarring, noninflammatory, permanent form of alopecia with an unknown etiology, often misdiagnosed as other types of alopecia.
CASE REPORT: A 27-year-old woman presented with triangular patches of alopecia in the temporal regions, resembling male pattern alopecia. Dermoscopy revealed normal follicular openings. Histopathological analysis showed only vellus follicles, with no telogen or terminal follicles, intact sebaceous glands, and no inflammatory infiltrate.
DISCUSSION: Dermoscopy is a valuable diagnostic tool, and histopathology may be performed in selected cases. There is no definitive treatment for TTA. Management options include topical minoxidil, hair transplantation, or surgical excision.

Keywords: Alopecia; Temporal Distribution; Hair Diseases.