Gynoid lipodystrophy (cellulite) is a common, unattractive dermatosis that affects many women around the world. Depending on the severity of the appearance, the condition may cause important psychosocial disorders. Many therapies have been clinically tested, and many have been proscribed, not only for their therapeutic inefficiency, but also for their risk to patients’ health. Other treatments, notwithstanding their weak scientific basis, are still in vogue. Medical devices, few of which are backed by actual scientific evidence, also currently claim to help treat this condition. This paper provides an extensive scientific literature review and analysis, and aims to help dermatologists decide what specific therapies to recommend and provide assurances regarding the clinical rationale of results when treating patients with this condition.

Keywords: CELLULITIS, LIPODYSTROPHY, ADIPOSE TISSUE

Keloids and hypertrophic scars result from abnormal wound healing with excessive growth of fibrous tissue. Despite the high incidence in the population, the high rates of relapse and the significant psychosocial impairment, treatment remains a challenge for dermatologists. The objective of this study was to review literature on clinical, etiological and therapeutical aspects of keloids and hypertrophic scars, emphasizing its therapy with bleomycin, demonstrating its effective and safe use. The search was conducted in Scopus and MEDLINE databases, for the period from 1995 to 2016, using the key words: queloide/keloid; cicatriz hipertrófica/cicatrix, hypertrophic; and bleomicina/bleomycin.

Keywords: KELOID; CICATRIX, HYPERTROPHIC; BLEOMYCIN

Alopecia areata is a relatively common autoimmune condition. It has an unpredictable course and its etiology has not yet been fully elucidated. Its treatment must be individualized, and aims at suppressing the phase of activity of the disease. Thus, many alternatives are available; however, none of them have been curative or preventive so far. We report the cases of two patients, aged 18 and 43 years, diagnosed with alopecia areata, who underwent topical immunotherapy with diphencyprone, and obtained different results. The application procedures, the results obtained and the clinical follow-up are described.

Keywords: THERAPEUTICS; IMMUNOTHERAPY; ALOPECIA AREATA; AUTOIMMUNE DISEASES