Introduction: Photodynamic therapy destroys target cells by directly harming them, injuring the vascular stroma, and activating the immune system.
Objective: To study photoaged skin''''''''s immune response to photodynamic therapy.
Methods: Thirteen female patients underwent three treatment sessions with delta 5-aminolevulinic acid combined with 630 nm diode light. The immunohistochemical response of the skin''''''''s immune system was evaluated using the markers anti-CD1a, anti-CD4+, anti-CD8+, anti-TNFa, anti-IFNy and anti-IL4 before, 24 hours after the first session, and 21 days after the third session.
Results: At the final evaluation, patients demonstrated a decrease in CD4 and CD8 lymphocytes, an increase in interleukin-4 in the epidermis and dermis, and a reduction and an increase of TNF-a in the epidermis and dermis, respectively. The Langerhans cell and INF-y populations remained unchanged.
Conclusion: Regarding the immune system, photodynamic therapy did not cause changes in Langerhans cells; therefore, there was little local immunosuppression. CD4 and CD8 lymphocyte apoptosis was observed, suggesting that photodynamic therapy can be useful in treating inflammatory diseases. The changes in TNF-a and an increase of IL4 in the dermis and epidermis suggest a humoral type response, which was also evidenced by the absence of INFy.

Keywords: PHOTOCHEMOTHERAPY, AMINOLEVULINIC ACID , SKIN AGING

Topical photodynamic therapy (TPT) is a well-established therapeutic modality in the treatment of non-melanoma skin cancer. It is based on light-activated chemical reaction in the presence of oxygen. In recent years, this therapy has been used in cosmiatric dermatology, and studies on the mechanisms of TPT action in dermal remodeling of the photodamaged skin have been reported. This review addresses procedures with different light sources and photosensitizers, as well as clinical and collateral effects of this therapy in the treatment of photoaging.

Keywords: PHOTODYNAMIC THERAPY, PHOTOSENSITIZER, PHOTOAGING, REJUVENATION, COLLAGEN, DERMIS

The ear is a structure with anatomical peculiarities. It is located in an area exposed to trauma and susceptible to a series of dermatoses that are often underdiagnosed by dermatologists and deserve attention. A literature review was carried out including the embryology and anatomy of the auricular pavilion, as well as the diagnosis and treatment of traumatic lesions of physical nature and due to changes in temperature, among others.

Keywords: Anatomy; Ear; Ear diseases

Knowledge, diagnostic ability and surgical skills for approaching diverse cutaneous conditions in the auricular region are parts of a dermatologist physician’s daily routine. In the second part of this review article, will be approached the benign neoplasms of the auricular region, describing their particularities and ideal methods of treatment.

Keywords: Ear; Nevus; Cysts; Keloid