Efficacy of a nutrient association on hair cycle regulation and keratinogenesis: molecular basis

Abstract

INTRODUCTION: Associated nutritional elements in physiological doses have demonstrated beneficial effects on capillary synthesis.
OBJECTIVE: To evaluate the impact of the association of nutrients on parameters related to the follicular unit’s integrity.
METHODS: An evaluation of the interaction of a nutritional Suplement versus an in vitro control was carried out in culture of human hair follicles, under four diverse markers: quantification of keratins 10 and 14; immunofluorescence evaluation of 17A1 collagen (COL17A1) protein expression; determination of β-catenin; and quantification of ATP synthesis.
RESULTS: There was a significant improvement (p <0.005) of all evaluated parameters. Histologic analysis demonstrated a significant increase in the presence of the collagen 17A1 under immunofluorescence.
CONCLUSIONS: The parameters evaluated in this study have highlighted the positive impact of the association of nutrients in the hair follicle and follicular papillary dermis, with an increase of cell proliferation and metabolism, as well increased presence of collagen 17A1.

Keywords: beta Catenin; Collagen; Hair follicle; Keratin-10; Keratin-14

THE CONTENT OF THIS ARTICLE IS NOT AVAILABLE FOR THIS LANGUAGE.