The importance of the early use of hyaluronidase in the treatment of arterial occlusion resulting from hyaluronic acid based cutaneous filling

Cutaneous ischemia, caused by arterial embolism, is one of the vascular adverse events resulting from the application of hyaluronic acid. Early application of hyaluronidase will lead to the successful degradation and reversal of the condition – which might be severe and cause harm to the patient. The authors report cases with suspected arterial occlusion in which degradation was performed with hyaluronidase at different timepoints. This analysis has evidenced that the degradation time and the procedure’s effectiveness are correlated to the intervention timepoint.

Keywords: Dermatology; Ischemia; Reperfusion