Malignant fibrous histiocytoma (MFH) or undifferentiated pleomorphic sarcoma (UPS) is a sarcoma capable of invading adjacent structures. It is a mesenchymal neoplasia that predominates in men between the sixth and seventh decades of life. It is located mainly in the lower limbs and may affect the head and neck, trunk, and retroperitoneum, presenting a tendency to recurrence and local metastasis. This report aims to present a case of MFH in the ankle of a 49-year-old woman with an adjacent bone invasion, which evolved with transtibial amputation. Clinical, radiological, histopathological, and therapeutic aspects were addressed, highlighting the importance of early diagnosis.

Keywords: Amputation; Malignant fibrous histiocytoma; Sarcoma

Piebaldism is a rare, autosomal dominant dyschromia characterized by circumscribed poliosis and triangular achromia in the frontal region in 90% of affected individuals, with no other systemic involvement. The incidence of dyschromia in this Dermatology Department, in a short space of time, and with plenty of images, motivated the presentation of this series of cases. We show two families with piebaldism, treated at the same Dermatology Department in 2021: the first family, with a mother and son presenting achromic macules on the trunk and poliosis in the frontal region since birth; the second family, with a grandmother, aunt, mother, and son showing the same characteristics described.

Keywords: Piebaldism; Pigmentation Disorders; Skin Diseases; Genetic

ABSTRACT

INTRODUCTION: Adult female acne (AFA) affects women over 25 years old. Although there are no solid data in the Brazilian literature, genetic, hormonal, and environmental factors are believed to contribute to its pathogenesis.
OBJECTIVE: To assess the prevalence of AFA and its possible risk factors in a sample of the Brazilian population.
METHODS: A cross-sectional clinical study was conducted with 258 women aged 25 to 55 stratified by race and age according to the Brazilian population (2010 census). The study analyzed their demographic, clinical, psychological, and exposure-related information.
RESULTS: Acne complaints were reported by 41.1% of participants, ranging from 15% in those aged 50–55 to 60% in those aged 25–29. Clinical examination confirmed lesions in 36.6% of women. In 70% of cases, acne had persisted since adolescence, and 13.2% of participants were undergoing treatment. Acne was significantly associated with age, race, age at menarche, hirsutism, smoking, oily skin, and makeup use (p<0.05).
CONCLUSIONS: Acne was a prevalent issue, especially before age 40, and was more common in Black and mixed-race individuals, those with clinical signs of hyperandrogenism, and makeup users. However, it was inversely associated with smoking.

Keywords: Acne Vulgaris; Adult; Hyperandrogenism.

Phenol peels are a deep chemical exfoliation technique used for decades for facial rejuvenation, acne scars, and hyperpigmentation. The Baker-Gordon formula is the most commonly used, providing effective results but with significant risks. The procedure requires anesthesia and strict postoperative care due to possible complications such as hyperpigmentation, hypopigmentation, infections, scarring, and systemic toxicity, especially cardiotoxicity. This descriptive and exploratory literature review, based on articles from 2000 to 2025, highlights the method’s effectiveness but emphasizes the need for further studies on its long-term safety and on proper patient management.

Keywords: Phenol; Chemexfoliation; Drug-Related Side Effects and Adverse Reactions