Atrophic acne scars result from an abnormal wound-healing response that can be treated with microneedling (MN). Insulin may play a role in wound healing. The effectiveness and safety of combining MN with topical insulin as an alternative therapy for atrophic acne scar revision have not yet been widely reported. We report the case of a 33-year-old woman with an atrophic acne scar on the middle third of her face. The patient was treated with MN and topical insulin for four sessions at two-week intervals. MN plus insulin can be considered an alternative for acne scar revision.

Keywords: Acne Vulgar; Insulina; Cicatriz; Hiperpigmentação

This study compared the effectiveness of secretome delivery using microneedling versus laser-assisted drug delivery for facial skin rejuvenation. The review included seven studies that demonstrated that both approaches were effective in delivering secretomes. However, microneedling had a higher patient satisfaction rate and fewer reported adverse events. We concluded that micro needling may be a more patient-friendly and safer option for facial rejuvenation. Further studies with larger sample sizes and extended follow-up periods are needed to confirm these results.

Keywords: Secretome; Laser Therapy; Systematic Review; Skin.