Clinical aesthetic effects of oral collagen oligopeptides on wrinkle appearance in women aged 45-60 years: a randomized, double-blind, placebo-controlled trial

INTRODUCTION: Oral collagen supplementation has been investigated as a strategy to support skin appearance, although clinical effects are generally modest. In aesthetic dermatology, both the magnitude and temporal pattern of changes are relevant.
OBJECTIVE: To assess the effects of oral supplementation with collagen oligopeptides on facial wrinkle appearance in women aged 45-60 years.
METHODS: A randomized, double-blind, placebo-controlled clinical trial was conducted in 102 women. Participants received collagen oligopeptides (2.5 g/day) or a placebo for 12 weeks. Wrinkle intensity was the primary endpoint, assessed using standardized digital imaging. Dermal density and collagen-related optical signals were analyzed as exploratory outcomes.
RESULTS: A significant reduction in wrinkle intensity was observed in the active group at week 8. A reduction was already apparent at week 4, although not statistically significant, and values remained numerically lower at week 12. The placebo group showed minor variations. Exploratory parameters showed numerical increases but were not statistically significant.
CONCLUSION: Collagen oligopeptide supplementation was associated with a reduction in wrinkle intensity, with an early effect that was partially maintained over time, indicating a measurable aesthetic benefit.

Keywords: Skin Aging; Collagen; Dietary Supplements; Peptides; Dermis