A tattoo results from the introduction of pigments into the skin or mucous membranes. Pigments are chemical substances that behave like optical markers. Their visibility (through epithelial transparency) is undeniable proof that cutaneous perfusion with micro-perforations is an effective procedure. This method was used to infuse Bleomycin sulfate in two patients bearing keloid lesions, employing the same equipment and components used by professional tattoo artists, with adaptations for dermatological use, and strictly observing aseptical and rational requirements.

Keywords: SURGICAL EQUIPMENT, THERAPEUTICS, KELOID, BLEOMYCIN

Systemic oral medications – such as cyclosporine (CYA) or methotrexate (MTX) – for the treatment of psoriasis have limited bioavailability due to incomplete gastrointestinal absorption and first-pass hepatic metabolism. Moreover, they are associated with adverse effects. The application of CYA or MTX using the microinfusion of drugs into the skin method (MMP^®) for the treatment of psoriasis vulgaris yielded a therapeutic response with significant reduction of lesions, and absence of side effects. In the present report, the authors describe 4 cases of psoriasis vulgaris treated using the MMP^® method, with the application of CYA or MTX.

Keywords: Cyclosporine; Methotrexate; Psoriasis