Effectiveness of 1% Centella asiatica ointment in women with melasma: A study on the Melasma Area and Severity Index (MASI) and patient satisfaction scores

INTRODUCTION: Melasma is a chronic dermatosis characterized by irregular hyperpigmented patches.
OBJECTIVES: To evaluate the effectiveness of topical Centella asiatica (CA) in treating melasma using the Melasma Area and Severity Index (MASI) Score and patient satisfaction.
METHODS: This single-blind randomized clinical trial (RCT) compared 1% CA ointment with 4% hydroquinone cream for 8 weeks, alongside daily sunscreen use. MASI score and patient satisfaction were measured before and after treatment, with adverse effects monitored throughout.
RESULTS: The CA group had a greater decrease in MASI scores but the difference between groups was not statistically significant. Patient satisfaction was similar between the two groups, with a slightly lower improvement in the CA group.
CONCLUSION: Both CA and hydroquinone significantly reduced MASI scores after 8 weeks, with no significant difference in effectiveness or patient satisfaction. CA may be considered a viable alternative for patients seeking comparable therapeutic outcomes with a lower risk of irritation.

Keywords: Skin Cream; Melanosis; Patient Satisfaction