In recent years, the use of probiotics in dermatology and cosmetology has been demonstrating a notable rise, offering both preventive and therapeutic benefits for the skin. The intestinal microbiota plays crucial roles, including enzymatic degradation of dietary fiber, starch, proteins, and fats, as well as the synthesis of vitamins B, K, nicotinic acid, amino acids, and various metabolites. The use of multicomponent probiotics composed of strains of the genus Bacillus is a promising way to optimize the positive effects of these microorganisms in dermatological and cosmetic practice and avoid their undesirable effects.

Keywords: Bacillus; Probiotics; Dermatology; Cosmetic Microbiology.

INTRODUCTION: Hair restoration treatments for alopecia using existing medications are not always effective, highlighting the need for new therapeutic options.
OBJECTIVE: This study aimed to evaluate the effects of a topical gel containing ethyl-methyl-hydroxypyridine succinate (EMHPS) on hair regrowth and biochemical and histological skin parameters in animals following chemical depilation.
METHODS: Experiments were conducted on 50 adult male Wistar rats. Alopecia was induced using a commercial depilatory product containing potassium thioglycolate. A 5% EMHPS gel (125 mg/kg) was applied daily to the depilated skin. Trichoscopy, biochemical analysis, and histological examination of skin samples were performed on days 3, 9, and 21 of treatment.
RESULTS: The EMHPS gel demonstrated a tendency to accelerate hair regrowth, reduce lipid peroxidation, normalize antioxidant enzyme activity, and restore hydroxyproline and glycosaminoglycan levels in the treated skin compared to the untreated pathology control.
CONCLUSIONS: The EMHPS gel primarily influences skin biochemical parameters and may be beneficial for treating forms of alopecia associated with oxidative stress.

Keywords: Hair; Hair Removal; Skin.