Surg Cosmet Dermatol. 2011;3(2):112-115
Introdução: Hyaluronic acid has been increasingly used in aesthetic procedures.
Objective: To evaluate the degree of improvement and duration of results in patients
who received treatment for wrinkles with hyaluronic acid.
Methods: Prospective, open, non-randomized, non-controlled study of 20 female patients who presented superficial wrinkles in the superior lips contour and a prominent nasolabial fold. The efficacy of hyaluronic acid was assessed using the Wrinkle Severity Rating Scale. The duration of results was assessed through biopsies. Safety was evaluated through clinical observation and reports of adverse events.
Results: A significant clinical improvement was observed after 15 days, which was sustained for 4 months. A minor worsening was observed after that period, although patients still presented favorable aesthetic results up to 12 months after the procedure. A majority of patients (n = 17) had a biopsy in the left retro-auricular region 180 days after the procedure. From this group, the substance was observed in 13 slides (76.4%).
Conclusion: Hyaluronic acid is an effective and safe product. This study has proven that the product remains in the dermis for up to 6 months.
Keywords: HYALURONIC ACID, RESIDENCE TIME, SKIN
All content the journal, except where identified, is under a Creative Commons Attribution-NonCommercial 4.0 International license - ISSN-e 1984-8773
