Surg Cosmet Dermatol. 2025;17(2):1-9
INTRODUCTION: Warts are a viral skin condition caused by the human papillomavirus (HPV), which can lead to disfigurement, embarrassment, and frustration. No single treatment has been shown to guarantee complete eradication.
OBJECTIVE: To evaluate and compare the effectiveness of topical potassium hydroxide (KOH) 40% and trichloroacetic acid (TCA) 40% in the treatment of plantar warts, based on clinical and dermoscopic outcomes, as well as to assess side effects and patient satisfaction.
METHODS: An interventional comparative study was conducted involving 33 patients with plantar warts. Lesions were divided into two groups: Group A received topical TCA 40%, and Group B received topical KOH 40%. All patients were evaluated both clinically and through dermoscopy.
RESULTS: Both treatment groups showed statistically significant clinical and dermoscopic improvement (p < 0.001 for both). Complete dermoscopic clearance without recurrence over a 2-month follow-up period was more frequent in the KOH group (88.6%).
CONCLUSION: Topical TCA and KOH were similarly effective. KOH, in particular, proved to be both effective and safe, making it a promising adjunct treatment for plantar warts alongside destructive and immunotherapeutic methods.
Keywords: Papillomaviridae. Warts. Controlled Clinical Trial
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