Surg Cosmet Dermatol. 2025;17(0):1-13
Vitamin C, or L-ascorbic acid, is the most abundant antioxidant in human skin and its topical replacement has proven relevant, since this reservoir is consumed by external aggression, and it is used in the prevention and treatment of skin aging. This review was based on bibliographic research in the PubMed and LILACS databases and two consensus meetings between the authors to analyze the evidence for its topical use. The highest level of evidence of skin activity has been found in the pure and stabilized form of ascorbic acid. Derivatives, carriers, and nanoformulas are being developed, however further clinical and comparative studies are needed.
Keywords: Ascorbic Acid; Antioxidants; Skin Aging; Hyperpigmentation; Cosmeceuticals.
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