Surg Cosmet Dermatol. 2025;17(0):1-3
INTRODUCTION: An 85% phenol and 4% croton oil solution (SFC) has cytotoxic effect on the epithelium; however, it has not been evaluated in the treatment of anogenital warts (AGW).
OBJECTIVE: To evaluate the effectiveness of SFC in the treatment of penile AGW in immunocompetent patients.
METHODS: Open, uncontrolled clinical trial (proof-of-concept), involving patients with penile AGW treated with SFC and reevaluated after 28 days.
RESULTS: We evaluated 16 treatments in 9 participants. SFC promoted total clearance of the lesions in 25% (95% CI 2-48%) of treatments.
CONCLUSIONS: Although well tolerated, SFC caused insufficient rates of total clearance.
Keywords: Condylomata Acuminata; Phenol; Papillomavirus Infections; Sexually Transmitted Diseases.
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