Bogdana Victoria Kadunc, Adriana Amorim Vanti
Surg Cosmet Dermatol. 2009;1(1):10-14
Abstract
PDF Portuguese
Introduction: Phenol has been used in medicine for several decades, but many aspects of its systemic toxicity are not completely known.
Objective: Evaluating the renal and cardiac toxicities of phenol absorbed percutaneously in facial peelings.
Material and methods: A prospective, comparative, randomized study was undertaken with 4 groups of 15 patients each, with 4 different types of facial peelings: pure, at 50 and 88% in continuous applications, pure at 88%, and associated with Baker’s Formula with applications at specific time intervals. Urinary levels of this substance were determined by gas chromatography and cardiac changes by a continuous electrocardiogram for 24 hours (Holter).
Results: Gas chromatography showed fast phenol elimination in the urine, with a half-life of 6 to 8 hours. Cardiac changes seen on the Holter were observed in all groups, which stopped immediately without medical intervention.
Conclusions: Phenol, used in facial peelings, does not affect renal function, but it can cause arrhythmias in susceptible individuals, which are not related with the concentration or technique used.
All content the journal, except where identified, is under a Creative Commons Attribution-NonCommercial 4.0 International license - ISSN-e 1984-8773
