Sociedade Brasileira de Dermatolodia Surgical & Cosmetic Dermatology


ISSN-e 1984-8773

Questoes e Gabaritos

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Desmoplastic melanoma


1. As a rule, desmoplastic melanoma (DM) presents the
following, except:
a. fibrous tumor
b. spindle cells that produce or liberate collagen
c. neurotropism, with a growth pattern similar to that of neuroma
d. hyperpigmentation
e. neural transformation
2. DM usually develops in:
a. areas with chronic photodamage
b. palmoplantar regions
c. genital or anal mucosa
d. lower limbs
e. scalp
3. DM’s pathogenic mechanism is based on the follo-
wing observations, with the exception of:
a. presence of premelanosomes in fibroblasts
b. positivity for S-100 protein and other melanocytic diffe- rentiation antigens
c. differentiation of melanocytes by fibroblastic phenotype
d. induction of collagen synthesis by fibroblastic prolifera- tion
e. collagen synthesis by melanoma cells
4. What precursor lesion is most frequently associated
with DM?
a. superficial extensive melanoma
b. lentigo maligna
c. acral lentiginous melanoma
d. atypical melanocytic nevi
e. acquired primary melanosis
5. Which of the following is not commonly observed in
DM’s histopathology?
a. atypical spindle cells’ fascicles
b. standard variable of desmoplasia, neurotropism, and neu- ral differentiation
c. collagenous stroma
d. invasion of the dermis and subcutaneous tissue
e. isolated and scattered inflammatory cells
6. Which antigen presents the greatest sensitivity in
DM’s immunohistochemical profile?
a. S-100 protein
b. HMB45
d. tyrosinase
e. melan-A/mart-1
7. Which of the following aspects is the least important
for surgical planning in DM?
a. more invasive behavior, particularly of the neurotrophic subtypes
b. lower rates of lymph node involvement
c. usual location in the head and neck
d. tumor thickness
e. increased rate of local recurrence
8. The most frequently affected organ in the event of
distant metastases in DM is:
a. liver
b. lungs
c. bones
d. central nervous system
e. kidneys
9. Which are less frequent dermoscopic characteristics
of DMs?
a. regression signs similar to scars
b. ”peppering” appearance
c. irregular linear vessels
d. milky-red areas
e. atypical pigment networ
10. The following entities can be cited in the differential
diagnosis of DM, except:
a. fibrosarcoma
b. Kaposi's sarcoma
c. amelanotic melanoma
d. fibromatosis
e. dermatofibroma

Gabarito do número anterior

1. D 2. C 3. B 4. B 5. C 6. D 7. B 8. C 9. D 10. C

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